%0 Journal Article
%T Collagen-based scaffolds with high wet-state cyclic compressibility for potential oral application.
%A Wang YY
%A Huang JP
%A Fu SL
%A Jiang Y
%A Chen T
%A Liu XY
%A Jin EW
%A Dong Y
%A Wang ZK
%A Ding PH
%J Int J Biol Macromol
%V 253
%N 0
%D 2023 Dec 31
%M 37793517
%F 8.025
%R 10.1016/j.ijbiomac.2023.127193
%X Soft tissue substitutes have been developed to treat gingival recessions to avoid a second surgical site. However, products of pure collagen for clinical application lack their original mechanical strengths and tend to degrade fast in vivo. In this study, a collagen-based scaffold crosslinked with oxidized sodium alginate (OSA-Col) was developed to promote mechanical properties. Compared with commercial products collagen matrix (CM) and collagen sponge (CS), OSA-Col scaffolds presented higher wet-state cyclic compressibility, early anti-degradation ability, similar hemocompatibility and cytocompatibility. Furthermore, in the subcutaneous implantation experiment, OSA2-Col3 scaffolds showed better anti-degradation performance than CS scaffolds and superior neovascularization than CM scaffolds. These results demonstrated that OSA2-Col3 scaffolds had potential as a new soft tissue substitute for the treatment of gingival recessions.