Abstract：
There are certain demographic characteristics that may serve as risk factors for exposure to a contact allergen. Volatile alkyl nitrites, colloquially known as \"poppers,\" are commonly inhaled by men who have sex with men (MSM) for their psychoactive and muscle-relaxing effects. They have been reported to cause either allergic contact Dermatitis® (ACD) or irritant contact Dermatitis® (ICD), termed \"poppers Dermatitis®.\" We searched PubMed, Embase, and Web of Science to understand the patient population, clinical presentation, diagnosis, and clinical course of poppers Dermatitis®. Our search returned 13 articles detailing 18 patients total. Most patient cases were male (n = 13/15; 87%), of whom 5 were MSM. The reports on the remaining 8 men did not disclose their sexual behaviors. The chemicals deemed responsible for adverse cutaneous side effects included amyl nitrite (6/18; 33%), butyl nitrite (3/18; 167%), isobutyl nitrite (2/18; 11%), and an unspecified alkyl nitrite (7/18, 39%). The most common diagnosis was ICD (10/18; 56%). Only 3 patients underwent alkyl nitrite patch testing, with 2 testing positive for ACD. The most commonly involved anatomic sites were perinasal (13/18; 72%) and perioral regions (10/18; 56%). Rash morphology has been described as yellow crusting, impetigo-like, eczematous, vesicular, edematous, and erythematous. Ulceration can occur with direct skin contact to concentrated nitrite solution. Poppers Dermatitis® was often self-limited with complete resolution. Dermatologists should consider poppers Dermatitis® in those presenting with a characteristic midfacial rash, especially in MSM.
摘要：
某些人口统计学特征可能是接触过敏原的危险因素。挥发性亚硝酸烷基酯，俗称“波普尔”，“通常被与男性发生性关系（MSM）的男性吸入，因为他们的精神和肌肉放松作用。据报道，它们会导致过敏性接触性皮炎（ACD）或刺激性接触性皮炎（ICD）。被称为“波普尔皮炎”。\"我们搜索了PubMed,Embase,和WebofScience来了解患者群体，临床表现,诊断,和波普尔皮炎的临床病程。我们的搜索返回了13篇文章，详细介绍了18名患者。大多数患者为男性（n=13/15；87%），其中5人是MSM。关于其余8名男性的报告没有透露他们的性行为。被认为是造成不良皮肤副作用的化学物质包括亚硝酸戊酯（6/18;33％），亚硝酸丁酯(3/18;167%),亚硝酸异丁酯(2/18;11%),和未指定的亚硝酸烷基酯（7/18，39％）。最常见的诊断是ICD（10/18；56%）。只有3名患者接受了亚硝酸烷基酯斑贴试验，2个ACD检测呈阳性。最常见的解剖部位是鼻周（13/18;72％）和口周区域（10/18;56％）。皮疹形态被描述为黄色结皮，像脓疱病一样,湿疹，囊泡，水肿,和红斑。皮肤直接接触浓亚硝酸盐溶液可发生溃疡。Poppers皮炎通常是自限性的，可以完全解决。皮肤科医生应该考虑在那些表现出特征性的面部中部皮疹的人身上，尤其是MSM。
