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Abstract：
BACKGROUND: Among present reports, the T/G allelic variation at the rs2609255 locus of the family sequence similarity gene 13A (FAM13A) was considerable associated with susceptibility to interstitial lung diseases (ILDs). In this study, we summarized relevant studies and applied a meta-analysis to explore whether the polymorphism of rs2609255 site of the FAM13A gene can be utilized to predict susceptibility to idiopathic pulmonary fibrosis (IPF) patients or rheumatoid arthritis-associated interstitial lung disease (RA-ILD) or silicosis patients in different populations for the first time.
METHODS: We compared the frequency of G allele on rs2609255 site of FAM13A between the control subjects and IPF or RA-ILD or silicosis patients from different races by using meta-analysis. Nine studies were involved in this meta-analysis, including five IPF studies, two RA-ILD studies, and two silicosis studies, and containing 14 subgroups. We conducted separate meta-analyses for different races.
RESULTS: In all individuals, a substantial link between the G allele of the FAM13A rs2609255 polymorphism and IPF (OR: 1.47, 95% CI: 1.33-1.63, p < 0.00001) was indicated. After dividing by ethnicity, the G allele was illustrated to be considerable correlation with IPF in Asian (OR: 2.63, 95% CI: 1.81-3.81, p < 0.00001) and with RA-ILD individuals (OR: 3.27, 95% CI: 1.26-8.49, p = 0.01). Conversely, there was no correlation with the G allele and IPF in European individuals (OR: 1.27, 95% CI: 0.89-1.83, p = 0.13) or silicosis in Chinese individuals (OR: 1.20, 95% CI: 0.99-1.46, p = 0.07).
CONCLUSIONS: This is the first meta-analysis that provides evidence that the rs2609255 of FAM13A might increase susceptibility to RA-ILD, and IPF especially in Asian but not in European individuals, and not be correlated with silicosis in Chinese individuals, which indicated the differences in susceptibility to disease by race were noteworthy.
METHODS: We compared the frequency of G allele on rs2609255 site of FAM13A between the control subjects and IPF or RA-ILD or silicosis patients from different races by using meta-analysis. Nine studies were involved in this meta-analysis, including five IPF studies, two RA-ILD studies, and two silicosis studies, and containing 14 subgroups. We conducted separate meta-analyses for different races.
RESULTS: In all individuals, a substantial link between the G allele of the FAM13A rs2609255 polymorphism and IPF (OR: 1.47, 95% CI: 1.33-1.63, p < 0.00001) was indicated. After dividing by ethnicity, the G allele was illustrated to be considerable correlation with IPF in Asian (OR: 2.63, 95% CI: 1.81-3.81, p < 0.00001) and with RA-ILD individuals (OR: 3.27, 95% CI: 1.26-8.49, p = 0.01). Conversely, there was no correlation with the G allele and IPF in European individuals (OR: 1.27, 95% CI: 0.89-1.83, p = 0.13) or silicosis in Chinese individuals (OR: 1.20, 95% CI: 0.99-1.46, p = 0.07).
CONCLUSIONS: This is the first meta-analysis that provides evidence that the rs2609255 of FAM13A might increase susceptibility to RA-ILD, and IPF especially in Asian but not in European individuals, and not be correlated with silicosis in Chinese individuals, which indicated the differences in susceptibility to disease by race were noteworthy.
摘要：
背景：在本报告中，家族序列相似性基因13A（FAM13A）的rs2609255位点的T/G等位基因变异与间质性肺病（ILD）的易感性密切相关。在这项研究中,我们总结了相关研究,并应用荟萃分析首次探讨FAM13A基因rs2609255位点多态性是否可用于预测不同人群中特发性肺纤维化(IPF)患者或类风湿性关节炎相关间质性肺病(RA-ILD)或矽肺患者的易感性.
方法：我们使用荟萃分析比较了对照受试者与不同种族的IPF或RA-ILD或矽肺患者之间FAM13Ars2609255位点的G等位基因频率。九项研究参与了这项荟萃分析，包括5项IPF研究,两项RA-ILD研究，和两项矽肺病研究，包含14个子组。我们对不同种族进行了单独的荟萃分析。
结果：在所有个体中，FAM13Ars2609255多态性的G等位基因与IPF之间存在实质性联系(OR:1.47,95%CI:1.33-1.63,p<0.00001).在按种族划分之后，在亚洲人群中,G等位基因与IPF(OR:2.63,95%CI:1.81-3.81,p<0.00001)和RA-ILD个体(OR:3.27,95%CI:1.26-8.49,p=0.01)显著相关。相反，欧洲个体G等位基因和IPF(OR:1.27,95%CI:0.89-1.83,p=0.13)与中国个体矽肺(OR:1.20,95%CI:0.99-1.46,p=0.07)无相关性。
结论：这是第一个提供证据表明FAM13A的rs2609255可能增加RA-ILD易感性的荟萃分析，IPF尤其是亚洲人，而不是欧洲人，与中国人的矽肺无关，这表明不同种族对疾病的易感性差异值得注意。
方法：我们使用荟萃分析比较了对照受试者与不同种族的IPF或RA-ILD或矽肺患者之间FAM13Ars2609255位点的G等位基因频率。九项研究参与了这项荟萃分析，包括5项IPF研究,两项RA-ILD研究，和两项矽肺病研究，包含14个子组。我们对不同种族进行了单独的荟萃分析。
结果：在所有个体中，FAM13Ars2609255多态性的G等位基因与IPF之间存在实质性联系(OR:1.47,95%CI:1.33-1.63,p<0.00001).在按种族划分之后，在亚洲人群中,G等位基因与IPF(OR:2.63,95%CI:1.81-3.81,p<0.00001)和RA-ILD个体(OR:3.27,95%CI:1.26-8.49,p=0.01)显著相关。相反，欧洲个体G等位基因和IPF(OR:1.27,95%CI:0.89-1.83,p=0.13)与中国个体矽肺(OR:1.20,95%CI:0.99-1.46,p=0.07)无相关性。
结论：这是第一个提供证据表明FAM13A的rs2609255可能增加RA-ILD易感性的荟萃分析，IPF尤其是亚洲人，而不是欧洲人，与中国人的矽肺无关，这表明不同种族对疾病的易感性差异值得注意。
