PDF(Pubmed)
Abstract：
Feline coronavirus (FCoV) is a ubiquitous RNA virus of cats, which is transmitted faeco-orally. In these guidelines, the European Advisory Board on Cat Diseases (ABCD) presents a comprehensive review of feline infectious peritonitis (FIP). FCoV is primarily an enteric virus and most infections do not cause clinical signs, or result in only enteritis, but a small proportion of FCoV-infected cats develop FIP. The pathology in FIP comprises a perivascular phlebitis that can affect any organ. Cats under two years old are most frequently affected by FIP. Most cats present with fever, anorexia, and weight loss; many have effusions, and some have ocular and/or neurological signs. Making a diagnosis is complex and ABCD FIP Diagnostic Approach Tools are available to aid veterinarians. Sampling an effusion, when present, for cytology, biochemistry, and FCoV RNA or FCoV antigen detection is very useful diagnostically. In the absence of an effusion, fine-needle aspirates from affected organs for cytology and FCoV RNA or FCoV antigen detection are helpful. Definitive diagnosis usually requires histopathology with FCoV antigen detection. Antiviral treatments now enable recovery in many cases from this previously fatal disease; nucleoside analogues (e.g., oral GS-441524) are very effective, although they are not available in all countries.
摘要：
猫冠状病毒（FCoV）是猫普遍存在的RNA病毒，它是经口传播的。在这些准则中,欧洲猫疾病咨询委员会（ABCD）对猫传染性腹膜炎（FIP）进行了全面审查。FCoV主要是一种肠道病毒，大多数感染不会引起临床症状，或者只导致肠炎,但是一小部分FCoV感染的猫发展为FIP。FIP中的病理包括可影响任何器官的血管周围静脉炎。两岁以下的猫最容易受到FIP的影响。大多数猫发烧，厌食症,和体重减轻；许多人有积液，和一些有眼睛和/或神经系统的迹象。做出诊断是复杂的，AB⑶FIP诊断方法工具可用于帮助兽医。取样积液，当存在时,细胞学，生物化学,和FCoVRNA或FCoV抗原检测在诊断上非常有用。在没有积液的情况下，从受影响的器官进行细胞学和FCoVRNA或FCoV抗原检测的细针抽吸是有帮助的。明确诊断通常需要FCoV抗原检测的组织病理学。现在，抗病毒治疗在许多情况下可以从这种先前致命的疾病中恢复；核苷类似物（例如，口服GS-441524)非常有效，尽管它们并非在所有国家都可用。
