关键词: CMA baked food cow’s milk allergy milk ladder tolerance acquisition

Mesh : Child Animals Cattle Female Infant Pregnancy Humans Food Hypersensitivity / therapy Milk Milk Hypersensitivity / therapy Milk Proteins Colostrum

来  源:   DOI:10.3390/nu15183921   PDF(Pubmed)

Abstract:
BACKGROUND: Cow\'s milk allergy (CMA) is one of the most common and complex food allergies affecting children worldwide and, with a few exceptions, presents in the first few months of life. Baked-milk-containing diets are well tolerated in the majority of milk-allergic children and allow dietary restrictions to be relaxed. In addition, the early introduction of tolerated forms of allergenic foods to an infant\'s diet in small amounts may enhance the outgrowth of their milk allergy through oral tolerance induction. The methods of milk introduction vary widely across the globe.
METHODS: We convened an expert group to develop a comprehensive milk ladder based on the calculated milk protein content of Indian foods. To validate the milk ladder, the foods chosen for the ladder were analyzed and the ladder was re-evaluated based on the cooked milk protein content.
RESULTS: Combining expert consensus and validation of milk protein content, we created the world\'s first milk ladder containing Indian foods. This is the first ladder that provides information on the timing and temperature of cooking, with validated milk protein content.
CONCLUSIONS: This is the first milk ladder based on the unique features of Indian food habits built by the consensus of Indian experts along with international collaboration with laboratory quantification of milk protein in each step. We believe the \"The Indian Milk Ladder\" will be a very helpful tool for pediatricians helping manage CMA in children as well as their parents and caregivers, not only in India, but in countries world-wide where these foods are commonly consumed.
摘要:
背景:牛奶过敏(CMA)是影响全球儿童的最常见和最复杂的食物过敏之一,除了少数例外,生命最初几个月的礼物。大多数牛奶过敏儿童对含烘焙牛奶的饮食耐受性良好,可以放松饮食限制。此外,早期在婴儿饮食中少量引入耐受形式的过敏食物,可能会通过口服耐受诱导促进牛奶过敏的生长。牛奶引入的方法在全球范围内差异很大。
方法:我们召集了一个专家组,根据计算出的印度食品的牛奶蛋白质含量,开发了一个全面的牛奶阶梯。为了验证牛奶梯子,分析了为梯子选择的食物,并根据煮熟的牛奶蛋白质含量对梯子进行了重新评估。
结果:结合专家共识和乳蛋白含量的验证,我们创造了世界上第一个含有印度食物的牛奶阶梯。这是第一个提供烹饪时间和温度信息的梯子,经过验证的牛奶蛋白质含量。
结论:这是第一个基于印度饮食习惯的独特特征的牛奶阶梯,由印度专家的共识以及在每个步骤中对牛奶蛋白进行实验室定量的国际合作建立。我们相信“印度牛奶阶梯”将是儿科医生帮助管理儿童及其父母和护理人员的CMA的非常有用的工具,不仅在印度,但是在世界范围内这些食物普遍消费的国家。
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