PDF(Pubmed)
Abstract：
Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient\'s condition. Ultimately the patient\'s aspirin was discontinued and he had no recurrence of angina or MI.
摘要：
Kounis综合征是由肥大细胞脱颗粒和炎症细胞活化引起的心绞痛或急性冠状动脉综合征。我们介绍了一例患有潜在的阿司匹林加重性呼吸系统疾病（AERD）且先前对阿司匹林过敏的患者。患者接受阿司匹林脱敏，然后用大剂量阿司匹林治疗。不幸的是,患者出现复发性心绞痛和心肌梗死(MI).许多左心导管检查显示血管痉挛是他的MI的病因；然而，增加血管扩张剂剂量的治疗对患者的病情没有改善。最终患者停用阿司匹林，他没有心绞痛或MI复发。
