{Reference Type}: Case Reports
{Title}: A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome.
{Author}: Shaw KM;Neaves BI;Springer HA;Coop CA;
{Journal}: Cureus
{Volume}: 15
{Issue}: 9
{Year}: 2023 Sep
暂无{DOI}: 10.7759/cureus.45635
{Abstract}: Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.