%0 Case Reports
%T A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome.
%A Shaw KM
%A Neaves BI
%A Springer HA
%A Coop CA
%J Cureus
%V 15
%N 9
%D 2023 Sep
%M 37736238
暂无%R 10.7759/cureus.45635
%X Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.