Abstract：
To report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs).
Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry.
The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence.
Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis.
Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry.
The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence.
Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis.
摘要：
目的：报告19例口腔孤立性纤维性肿瘤（SFTs）的临床病理特征。
方法：从7个病理服务机构的记录中收集临床数据。所有病例均通过HE染色重新评估，并通过免疫组织化学证实。
结果：该系列包括11名女性（57.9％）和8名男性（42.1％），平均年龄为47.3±14.7岁（范围：22-71岁），男女比例为1.3：1。大多数肿瘤影响颊粘膜（n=7；36.8％），临床上表现为无症状的孤立性粘膜下结节，其颜色类似于口腔粘膜。形态学上,大多数SFT（n=10；52.6％）表现出经典的混合模式，其特征是在可变的胶原性血管基质中，密集细胞区域与低细胞区域交替增殖。2例（n=2；10.5％）观察到副唾液腺残留物。所有肿瘤均为STAT6和CD34阳性(n=19;100%)。结果信息可从6例患者（31.6%）获得，临床随访6至24个月(平均值±SD，9.5±6.8个月)，没有发生局部复发。
结论：口服SFT罕见，临床上常被误诊。病理学家在口腔梭形细胞肿瘤的鉴别诊断中应考虑SFT。准确的诊断需要免疫组织化学分析支持的仔细形态学评估。
方法：从7个病理服务机构的记录中收集临床数据。所有病例均通过HE染色重新评估，并通过免疫组织化学证实。
结果：该系列包括11名女性（57.9％）和8名男性（42.1％），平均年龄为47.3±14.7岁（范围：22-71岁），男女比例为1.3：1。大多数肿瘤影响颊粘膜（n=7；36.8％），临床上表现为无症状的孤立性粘膜下结节，其颜色类似于口腔粘膜。形态学上,大多数SFT（n=10；52.6％）表现出经典的混合模式，其特征是在可变的胶原性血管基质中，密集细胞区域与低细胞区域交替增殖。2例（n=2；10.5％）观察到副唾液腺残留物。所有肿瘤均为STAT6和CD34阳性(n=19;100%)。结果信息可从6例患者（31.6%）获得，临床随访6至24个月(平均值±SD，9.5±6.8个月)，没有发生局部复发。
结论：口服SFT罕见，临床上常被误诊。病理学家在口腔梭形细胞肿瘤的鉴别诊断中应考虑SFT。准确的诊断需要免疫组织化学分析支持的仔细形态学评估。
