This was a retrospective observational study, a total of 1248 children with AR were enrolled at the Third People\'s Hospital of Changzhou between January 2018 and December 2019. The serum-specific immunoglobulin E (sIgE) to 19 kinds of inhaled and food allergens and serum total IgE were detected with the AllergyScreen test (Mediwiss Analytic GmbH, Moers, Germany). All participants had a positive reaction to at least one allergen in the test (the sIgE concentration ≥ 0.35 IU/ml).
Among the patients, 818 (65.54%) were male and 430 (34.46%) were female, with 81 (6.50%) aged 1-3 year, 501 (40.14%) aged 4-7 year, and 666 (53.36%) aged 8-14 year. The positivity rate of inhaled allergens was 80.05% (n = 999), while the positivity rate of food allergens was 66.19% (n = 826). 828 patients (66.35%) were sensitized to multiple allergens. The most common inhaled allergens were Dermatophagoides pteronyssinus (65.38%), mold mix (25.56%), house dust (20.67%), and dog hair dander (13.94%), and the most common food allergens were cow\'s milk (30.31%), cashew nut (27.9%), egg (22.68%), and beef (12.98%). With an increase in age, the inhaled allergen positivity rate showed a significant increase (P < 0.01), while the food allergen positivity rate decreased significantly (P < 0.01). There were significant age differences in total IgE levels (P < 0.01) and the total IgE level was highest in the group aged 8-14 year.
Dermatophagoides pteronyssinus was the most common sensitizing allergen in pediatric patients with AR in Changzhou. Several other inhaled and food allergens were also common. We observed that multiple allergenic factors play an important role in the occurrence and development of AR.
方法:这是一项回顾性观察研究,2018年1月至2019年12月,常州市第三人民医院共纳入1248例AR患儿.用AllergyScreen试验检测19种吸入和食物过敏原的血清特异性免疫球蛋白E(sIgE)和血清总IgE(MediwissAnalyticGmbH,Moers,德国)。所有参与者对测试中的至少一种过敏原均呈阳性反应(sIgE浓度≥0.35IU/ml)。
结果:在患者中,男性818人(65.54%),女性430人(34.46%),81岁(6.50%)1-3岁,501(40.14%)4-7岁,8-14岁的666人(53.36%)。吸入性过敏原阳性率为80.05%(n=999),食物过敏原阳性率为66.19%(n=826)。828例(66.35%)患者对多种过敏原致敏。最常见的吸入性变应原为翼状尘螨(65.38%),模具混合(25.56%),房屋灰尘(20.67%),和狗毛皮屑(13.94%),最常见的食物过敏原是牛奶(30.31%),腰果(27.9%),鸡蛋(22.68%),牛肉(12.98%)。随着年龄的增长,吸入性变应原阳性率显著升高(P<0.01),食物过敏原阳性率明显降低(P<0.01)。总IgE水平存在显著的年龄差异(P<0.01),8-14岁组总IgE水平最高。
结论:翼状螨是常州地区儿童AR患者最常见的致敏变应原。其他几种吸入和食物过敏原也很常见。我们观察到多种致敏因素在AR的发生和发展中起重要作用。