Abstract：
LP007-1 is a variety of insect-resistant and herbicide-tolerant maize containing the modified cry1Ab, cry2Ab, vip3Aa and cp4-epsps genes. The food safety assessment of the maize LP007-1 was conducted in Wistar Han RCC rats by a 90-days feeding study. Maize grains from both LP007-1 or its corresponding non-genetically modified control maize AX808 were incorporated into rodent diets at 25% and 50% concentrations by mass and administered to rats (n = 10/sex/group) for 90 days. A commercialized rodent diet was fed to an additional group as the basal-diet group. The diets of all groups were nutritionally balanced. No biologically relevant differences were observed in rats fed with maize LP007-1 compared to rats fed with AX808 and the basal-diet with respect to body weight/gain, food consumption/utilization, clinical signs, mortality, ophthalmology, clinical pathology (hematology, prothrombin time, activation of partial thrombin time, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. Considering the circumstances of this study, the results provided evidence that LP007-1 maize did not exhibit toxicity in the 90-day feeding study.
摘要：
LP007-1是一种含有改良的cry1Ab的抗虫和耐除草剂玉米，cry2Ab,vip3Aa和cp4-epsps基因。通过90天喂养研究，在WistarHanRCC大鼠中进行了玉米LP007-1的食品安全评估。将来自LP007-1或其相应的非转基因对照玉米AX808的玉米谷物以25％和50％的质量浓度掺入啮齿动物饮食中，并给予大鼠（n=10/性别/组）90天。将商业化的啮齿动物饮食喂给另一组作为基础饮食组。所有组的饮食营养均衡。与用AX808和基础饮食喂养的大鼠相比，用玉米LP007-1喂养的大鼠在体重/增长方面没有观察到生物学相关的差异。食物消费/利用，临床体征,死亡率,眼科,临床病理学(血液学，凝血酶原时间,部分凝血酶时间的激活，血清化学,尿液分析)，器官重量,以及大体和显微病理学。考虑到本研究的情况，结果提供了证据,证明LP007-1玉米在90天饲喂研究中没有表现出毒性.
