PDF(Pubmed)
Abstract：
UNASSIGNED: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults.
UNASSIGNED: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age.
UNASSIGNED: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of -2.08 mL/year (95% confidence interval: -2.79, -1.36) and in FVC of -2.86 mL/year (-3.73, -1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio.
UNASSIGNED: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period.
UNASSIGNED: German Research Foundation.
UNASSIGNED: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age.
UNASSIGNED: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of -2.08 mL/year (95% confidence interval: -2.79, -1.36) and in FVC of -2.86 mL/year (-3.73, -1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio.
UNASSIGNED: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period.
UNASSIGNED: German Research Foundation.
摘要：
■虽然短期环境臭氧暴露对肺功能的不利影响是有据可查的，长期暴露的影响仍然知之甚少，尤其是成年人。
■我们旨在研究长期臭氧暴露与肺功能下降之间的关联。3014名参与者来自八个国家的17个中心，所有这些都来自欧洲共同体呼吸健康调查（ECRHS）。在大约35、44和55岁时，进行了肺活量测定以测量支气管扩张前1s的用力呼气量（FEV1）和用力肺活量（FVC）。我们将每日最大运行8小时平均臭氧浓度的年平均值分配给各个住宅地址。对PM2.5、NO2和绿色进行了调整。为了捕获与臭氧相关的肺活量测定参数的变化，我们的线性混合效应回归模型包括长期臭氧暴露和年龄之间的相互作用项.
■平均环境臭氧浓度约为65μg/m3。臭氧的四分位数范围增加了7μg/m3，这与FEV1的-2.08mL/年（95％置信区间：-2.79，-1.36）和FVC的-2.86mL/年（-3.73，-1.99）mL/年在研究期间。在调整了PM2.5、NO2和绿色度之后，关联表现强劲。这种关联在北欧居民和基线年龄较大的个体中更为明显。未检测到与FEV1/FVC比值的一致关联。
■长期暴露于升高的环境臭氧浓度与20年期间欧洲中年成年人肺活量测定肺功能的更快下降有关。
■德国研究基金会。
■我们旨在研究长期臭氧暴露与肺功能下降之间的关联。3014名参与者来自八个国家的17个中心，所有这些都来自欧洲共同体呼吸健康调查（ECRHS）。在大约35、44和55岁时，进行了肺活量测定以测量支气管扩张前1s的用力呼气量（FEV1）和用力肺活量（FVC）。我们将每日最大运行8小时平均臭氧浓度的年平均值分配给各个住宅地址。对PM2.5、NO2和绿色进行了调整。为了捕获与臭氧相关的肺活量测定参数的变化，我们的线性混合效应回归模型包括长期臭氧暴露和年龄之间的相互作用项.
■平均环境臭氧浓度约为65μg/m3。臭氧的四分位数范围增加了7μg/m3，这与FEV1的-2.08mL/年（95％置信区间：-2.79，-1.36）和FVC的-2.86mL/年（-3.73，-1.99）mL/年在研究期间。在调整了PM2.5、NO2和绿色度之后，关联表现强劲。这种关联在北欧居民和基线年龄较大的个体中更为明显。未检测到与FEV1/FVC比值的一致关联。
■长期暴露于升高的环境臭氧浓度与20年期间欧洲中年成年人肺活量测定肺功能的更快下降有关。
■德国研究基金会。
