PDF(Pubmed)
Abstract：
BACKGROUND: The role of diet in the pathogenesis and treatment of chronic enteropathies (CE) in dogs is unresolved.
OBJECTIVE: To compare the ability of diets composed of hydrolyzed fish, rice starch, and fish oil without (HF) or with prebiotics, turmeric, and high cobalamin (HF+) against a limited ingredient diet containing mixed nonhydrolyzed antigens and oils (control) to resolve clinical signs and maintain serum cobalamin and folate concentrations in dogs with nonprotein losing CE (non-PLE). To determine the ability of hydrolyzed fish diets to support recovery and remission in dogs with PLE.
METHODS: Thirty-one client-owned dogs with CE: 23 non-PLE, 8 PLE.
METHODS: Randomized, blinded, controlled trial. Diets were fed for 2 weeks; responders continued for 12 weeks. Nonresponders were crossed over to another diet for 12 weeks. Response was determined by standardized clinical evaluation with long-term follow-up at 26 weeks. Concurrent medications were allowed in PLE.
RESULTS: Nineteen of 23 (83%; 95% confidence interval [CI], 60%-94%) non-PLE CE responded clinically to their initial diet, with no difference between diets (P > .05). Four nonresponders responded to another diet, with sustained remission of 18/18 (100%; 95%CI, 78%-100%) at 26 weeks. Serum cobalamin concentration was increased (P < .05) and maintained by diet. Serum folate concentration decreased posttreatment (P < .05) but was restored by dietary supplementation. Hydrolyzed fish diets supported weight gain, serum albumin concentration, and recovery (P < .05) in dogs with PLE.
CONCLUSIONS: Changing diet, independent of antigen restriction or supplemental ingredients, induced long-term remission in dogs with non-PLE CE. Serum cobalamin and folate concentrations were maintained by diet. Hydrolyzed fish diets supported clinical recovery and remission in PLE.
OBJECTIVE: To compare the ability of diets composed of hydrolyzed fish, rice starch, and fish oil without (HF) or with prebiotics, turmeric, and high cobalamin (HF+) against a limited ingredient diet containing mixed nonhydrolyzed antigens and oils (control) to resolve clinical signs and maintain serum cobalamin and folate concentrations in dogs with nonprotein losing CE (non-PLE). To determine the ability of hydrolyzed fish diets to support recovery and remission in dogs with PLE.
METHODS: Thirty-one client-owned dogs with CE: 23 non-PLE, 8 PLE.
METHODS: Randomized, blinded, controlled trial. Diets were fed for 2 weeks; responders continued for 12 weeks. Nonresponders were crossed over to another diet for 12 weeks. Response was determined by standardized clinical evaluation with long-term follow-up at 26 weeks. Concurrent medications were allowed in PLE.
RESULTS: Nineteen of 23 (83%; 95% confidence interval [CI], 60%-94%) non-PLE CE responded clinically to their initial diet, with no difference between diets (P > .05). Four nonresponders responded to another diet, with sustained remission of 18/18 (100%; 95%CI, 78%-100%) at 26 weeks. Serum cobalamin concentration was increased (P < .05) and maintained by diet. Serum folate concentration decreased posttreatment (P < .05) but was restored by dietary supplementation. Hydrolyzed fish diets supported weight gain, serum albumin concentration, and recovery (P < .05) in dogs with PLE.
CONCLUSIONS: Changing diet, independent of antigen restriction or supplemental ingredients, induced long-term remission in dogs with non-PLE CE. Serum cobalamin and folate concentrations were maintained by diet. Hydrolyzed fish diets supported clinical recovery and remission in PLE.
摘要：
背景：饮食在犬慢性肠病（CE）的发病机理和治疗中的作用尚未解决。
目的：为了比较水解鱼组成的饮食的能力，大米淀粉,和不含(HF)或益生元的鱼油，姜黄,和高钴胺素（HF）对抗含有混合的非水解抗原和油（对照）的有限成分饮食，以解决临床症状并维持非蛋白质丢失CE（非PLE）的狗的血清钴胺素和叶酸浓度。确定水解鱼日粮支持PLE犬恢复和缓解的能力。
方法：31只客户拥有CE的狗：23只非PLE，8PLE。
方法：随机化，失明,对照试验。饮食喂养2周;应答者持续12周。无反应者被交叉接受另一种饮食12周。通过标准化临床评估和26周的长期随访确定反应。在PLE中允许同时用药。
结果：23个中的19个（83％；95％置信区间[CI]，60%-94%)非PLECE对他们最初的饮食有临床反应，饮食之间没有差异（P>0.05）。四个无应答者对另一种饮食做出了反应，26周时持续缓解18/18（100％；95CI，78％-100％）。血清钴胺浓度增加（P<0.05），并通过饮食维持。治疗后血清叶酸浓度降低（P<0.05），但通过饮食补充可以恢复。水解鱼的饮食支持体重增加，血清白蛋白浓度,和恢复（P<0.05）的狗与PLE。
结论：改变饮食，独立于抗原限制或补充成分，在非PLECE犬中诱导长期缓解。通过饮食维持血清钴胺素和叶酸浓度。水解鱼的饮食支持PLE的临床恢复和缓解。
目的：为了比较水解鱼组成的饮食的能力，大米淀粉,和不含(HF)或益生元的鱼油，姜黄,和高钴胺素（HF）对抗含有混合的非水解抗原和油（对照）的有限成分饮食，以解决临床症状并维持非蛋白质丢失CE（非PLE）的狗的血清钴胺素和叶酸浓度。确定水解鱼日粮支持PLE犬恢复和缓解的能力。
方法：31只客户拥有CE的狗：23只非PLE，8PLE。
方法：随机化，失明,对照试验。饮食喂养2周;应答者持续12周。无反应者被交叉接受另一种饮食12周。通过标准化临床评估和26周的长期随访确定反应。在PLE中允许同时用药。
结果：23个中的19个（83％；95％置信区间[CI]，60%-94%)非PLECE对他们最初的饮食有临床反应，饮食之间没有差异（P>0.05）。四个无应答者对另一种饮食做出了反应，26周时持续缓解18/18（100％；95CI，78％-100％）。血清钴胺浓度增加（P<0.05），并通过饮食维持。治疗后血清叶酸浓度降低（P<0.05），但通过饮食补充可以恢复。水解鱼的饮食支持体重增加，血清白蛋白浓度,和恢复（P<0.05）的狗与PLE。
结论：改变饮食，独立于抗原限制或补充成分，在非PLECE犬中诱导长期缓解。通过饮食维持血清钴胺素和叶酸浓度。水解鱼的饮食支持PLE的临床恢复和缓解。
