OBJECTIVE: To compare the ability of diets composed of hydrolyzed fish, rice starch, and fish oil without (HF) or with prebiotics, turmeric, and high cobalamin (HF+) against a limited ingredient diet containing mixed nonhydrolyzed antigens and oils (control) to resolve clinical signs and maintain serum cobalamin and folate concentrations in dogs with nonprotein losing CE (non-PLE). To determine the ability of hydrolyzed fish diets to support recovery and remission in dogs with PLE.
METHODS: Thirty-one client-owned dogs with CE: 23 non-PLE, 8 PLE.
METHODS: Randomized, blinded, controlled trial. Diets were fed for 2 weeks; responders continued for 12 weeks. Nonresponders were crossed over to another diet for 12 weeks. Response was determined by standardized clinical evaluation with long-term follow-up at 26 weeks. Concurrent medications were allowed in PLE.
RESULTS: Nineteen of 23 (83%; 95% confidence interval [CI], 60%-94%) non-PLE CE responded clinically to their initial diet, with no difference between diets (P > .05). Four nonresponders responded to another diet, with sustained remission of 18/18 (100%; 95%CI, 78%-100%) at 26 weeks. Serum cobalamin concentration was increased (P < .05) and maintained by diet. Serum folate concentration decreased posttreatment (P < .05) but was restored by dietary supplementation. Hydrolyzed fish diets supported weight gain, serum albumin concentration, and recovery (P < .05) in dogs with PLE.
CONCLUSIONS: Changing diet, independent of antigen restriction or supplemental ingredients, induced long-term remission in dogs with non-PLE CE. Serum cobalamin and folate concentrations were maintained by diet. Hydrolyzed fish diets supported clinical recovery and remission in PLE.
目的:为了比较水解鱼组成的饮食的能力,大米淀粉,和不含(HF)或益生元的鱼油,姜黄,和高钴胺素(HF)对抗含有混合的非水解抗原和油(对照)的有限成分饮食,以解决临床症状并维持非蛋白质丢失CE(非PLE)的狗的血清钴胺素和叶酸浓度。确定水解鱼日粮支持PLE犬恢复和缓解的能力。
方法:31只客户拥有CE的狗:23只非PLE,8PLE。
方法:随机化,失明,对照试验。饮食喂养2周;应答者持续12周。无反应者被交叉接受另一种饮食12周。通过标准化临床评估和26周的长期随访确定反应。在PLE中允许同时用药。
结果:23个中的19个(83%;95%置信区间[CI],60%-94%)非PLECE对他们最初的饮食有临床反应,饮食之间没有差异(P>0.05)。四个无应答者对另一种饮食做出了反应,26周时持续缓解18/18(100%;95CI,78%-100%)。血清钴胺浓度增加(P<0.05),并通过饮食维持。治疗后血清叶酸浓度降低(P<0.05),但通过饮食补充可以恢复。水解鱼的饮食支持体重增加,血清白蛋白浓度,和恢复(P<0.05)的狗与PLE。
结论:改变饮食,独立于抗原限制或补充成分,在非PLECE犬中诱导长期缓解。通过饮食维持血清钴胺素和叶酸浓度。水解鱼的饮食支持PLE的临床恢复和缓解。