{Reference Type}: Randomized Controlled Trial, Veterinary
{Title}: Randomized controlled trial of hydrolyzed fish diets in dogs with chronic enteropathy.
{Author}: Simpson KW;Miller ML;Loftus JP;Rishniw M;Frederick CE;Wakshlag JJ;
{Journal}: J Vet Intern Med
{Volume}: 37
{Issue}: 6
{Year}: 2023 Nov-Dec 7
{Factor}: 3.175
{DOI}: 10.1111/jvim.16844
{Abstract}: <B>BACKGROUND: </B>The role of diet in the pathogenesis and treatment of chronic enteropathies (CE) in dogs is unresolved.<BR><B>OBJECTIVE: </B>To compare the ability of diets composed of hydrolyzed fish, rice starch, and fish oil without (HF) or with prebiotics, turmeric, and high cobalamin (HF+) against a limited ingredient diet containing mixed nonhydrolyzed antigens and oils (control) to resolve clinical signs and maintain serum cobalamin and folate concentrations in dogs with nonprotein losing CE (non-PLE). To determine the ability of hydrolyzed fish diets to support recovery and remission in dogs with PLE.<BR><B>METHODS: </B>Thirty-one client-owned dogs with CE: 23 non-PLE, 8 PLE.<BR><B>METHODS: </B>Randomized, blinded, controlled trial. Diets were fed for 2 weeks; responders continued for 12 weeks. Nonresponders were crossed over to another diet for 12 weeks. Response was determined by standardized clinical evaluation with long-term follow-up at 26 weeks. Concurrent medications were allowed in PLE.<BR><B>RESULTS: </B>Nineteen of 23 (83%; 95% confidence interval [CI], 60%-94%) non-PLE CE responded clinically to their initial diet, with no difference between diets (P > .05). Four nonresponders responded to another diet, with sustained remission of 18/18 (100%; 95%CI, 78%-100%) at 26 weeks. Serum cobalamin concentration was increased (P < .05) and maintained by diet. Serum folate concentration decreased posttreatment (P < .05) but was restored by dietary supplementation. Hydrolyzed fish diets supported weight gain, serum albumin concentration, and recovery (P < .05) in dogs with PLE.<BR><B>CONCLUSIONS: </B>Changing diet, independent of antigen restriction or supplemental ingredients, induced long-term remission in dogs with non-PLE CE. Serum cobalamin and folate concentrations were maintained by diet. Hydrolyzed fish diets supported clinical recovery and remission in PLE.