Abstract：
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI. In addition, higher levels of DHEAS, DHEA, and cortisone were found in c-AEFI which persisted at follow-up. No anti-heart muscle and anti-endothelial cell antibodies have been detected. Overall current comparative data showed a distinct inflammatory and androgens profile in c-AEFI patients which results to be well restricted on heart and to persist months after the acute event.
摘要：
尽管接种疫苗有多重好处，已经报道了COVID-19免疫（c-AEFI）后的心脏不良事件。这些事件以及儿童多系统炎症综合征（MIS-C）中报道的严重心脏受累在年轻成年男性中更为常见。在这里，我们首先报告了c-AEFI患者的炎症状况与年龄的比较，青春期年龄和性别与心脏受累的MIS-C相匹配。在MIS-C中发现与全身性炎症相关的蛋白质高于c-AEFI，而在c-AEFI中发现与心肌损伤相关的蛋白质水平较高。此外,更高水平的DHEAS,DHEA,在c-AEFI中发现可的松，并在随访中持续存在。没有检测到抗心肌和抗内皮细胞抗体。目前的总体比较数据显示c-AEFI患者中不同的炎症和雄激素谱,其结果是在急性事件后对心脏很好地限制并持续数月。
