PDF(Pubmed)
Abstract：
Upregulation of neuroplasticity might help maximize stroke recovery. One intervention that appears worthy of investigation is aerobic exercise. This study aimed to determine whether a single bout of moderate intensity aerobic exercise can enhance neuroplasticity in people with stroke. Participants were randomly assigned (1:1) to a 20-min moderate intensity exercise intervention or remained sedentary (control). Transcranial magnetic stimulation measured corticospinal excitability of the contralesional hemisphere by recording motor evoked potentials (MEPs). Intermittent Theta Burst Stimulation (iTBS) was used to repetitively activate synapses in the contralesional primary motor cortex, initiating the early stages of neuroplasticity and increasing excitability. It was surmised that if exercise increased neuroplasticity, there would be a greater facilitation of MEPs following iTBS. Thirty-three people with stroke participated in this study (aged 63.87 ± 10.30 years, 20 male, 6.13 ± 4.33 years since stroke). There was an interaction between Time*Group on MEP amplitudes (P = 0.009). Participants allocated to aerobic exercise had a stronger increase in MEP amplitude following iTBS. A non-significant trend indicated time since stroke might moderate this interaction (P = 0.055). Exploratory analysis suggested participants who were 2-7.5 years post stroke had a strong MEP facilitation following iTBS (P < 0.001). There was no effect of age, sex, resting motor threshold, self-reported physical activity levels, lesion volume or weighted lesion load (all P > 0.208). Moderate intensity cycling may enhance neuroplasticity in people with stroke. This therapy adjuvant could provide opportunities to maximize stroke recovery.
摘要：
神经可塑性的上调可能有助于最大化中风恢复。一种似乎值得研究的干预措施是有氧运动。这项研究旨在确定单次中等强度有氧运动是否可以增强中风患者的神经可塑性。参与者被随机分配（1：1）接受20分钟的中等强度运动干预或保持久坐（对照）。经颅磁刺激通过记录运动诱发电位（MEP）测量对侧半球的皮质脊髓兴奋性。间歇性Theta爆发刺激（iTBS）用于反复激活对侧初级运动皮层的突触，启动神经可塑性的早期阶段并增加兴奋性。据推测，如果运动增加神经可塑性，iTBS之后，欧洲议会议员将得到更大的便利。33名中风患者参加了这项研究（年龄63.87±10.30岁，20男,卒中后6.13±4.33年）。在MEP振幅上，Time*Group之间存在相互作用（P=0.009）。分配给有氧运动的参与者在iTBS后的MEP振幅增加更强。非显著趋势表明中风后的时间可能会缓和这种相互作用(P=0.055)。探索性分析表明，卒中后2-7.5年的参与者在iTBS后有很强的MEP促进(P<0.001)。没有年龄的影响，性别,静止运动阈值，自我报告的身体活动水平，病变体积或加权病变负荷(均P>0.208)。中等强度的循环可以增强中风患者的神经可塑性。这种辅助疗法可以提供最大化中风恢复的机会。
