Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.

表征在人源化小鼠中连续传代后流行前 HIV - 2 组 F 病毒的表型和遗传变化。

• 影响指数: 0.821
• 发表时间: 2023 10 1
• 来源期刊: J Med Primatol
• DOI: 10.1111/jmp.12674
• PMID: 37658590
• 文章类型: Journal Article
• 中科院分区: Q3;Q3
• 作者列表: Curlin JZ,Schmitt K,Remling-Mulder L,Tibbitts CV,O'Connor S,Marx P,Akkina R

关键词: HIV-2 group F; hu-HSC mice and HIV evolution; humanized mice; serial passaging; viral evolution

Mesh: Humans; Animals; Mice; HIV-2 / genetics; Serial Passage; Viral Load

Abstract

HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

摘要

仅从两个个体中分离出具有NHP起源的HIV-2F组病毒。hu-小鼠中的两个连续传代显示病毒载量增加，CD4+T细胞下降和非同义遗传变化显示其进一步进化的能力，并在人类中传播。