{Reference Type}: Journal Article
{Title}: Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.
{Author}: Curlin JZ;Schmitt K;Remling-Mulder L;Tibbitts CV;O'Connor S;Marx P;Akkina R;
{Journal}: J Med Primatol
{Volume}: 52
{Issue}: 5
{Year}: 2023 10 1
{Factor}: 0.821
{DOI}: 10.1111/jmp.12674
{Abstract}: HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.