%0 Journal Article
%T Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.
%A Curlin JZ
%A Schmitt K
%A Remling-Mulder L
%A Tibbitts CV
%A O'Connor S
%A Marx P
%A Akkina R
%J J Med Primatol
%V 52
%N 5
%D 2023 10 1
%M 37658590
%F 0.821
%R 10.1111/jmp.12674
%X HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.