Abstract：
OBJECTIVE: To compare the clinical, radiographic, and immunological outcomes between one-piece versus two-piece zirconia abutments supported single implant crowns in the esthetic region.
METHODS: The study followed a split-mouth, double-blind, and randomized controlled clinical design for a duration of 3 years. Twenty-two eligible patients with 44 implants were randomly assigned to two groups: Group 1 (one-piece zirconia abutment with zirconia base, n = 22) and Group 2 (two-piece zirconia abutment with titanium base, n = 22). The primary outcome was the technical complication rate. Additionally, survival rates, cytokines concentrations in peri-implant crevicular fluid (PICF), peri-implant conditions, marginal bone loss, and pink/white esthetics score (PES/WES) were assessed as secondary outcomes.
RESULTS: Twelve of 22 patients attended the 1-year follow-up (due to the COVID pandemic), and 19 patients attended the 3-year examination. Two abutments in Group 1 were fractured after 10 and 12 months in function. Additionally, one screw loosening occurred in Group 1 at 1-year follow-up. The 3-year technical complication rate was significantly higher in Group 1 than that in Group 2 (15.79% vs. 0%, p < .001). The 3-year implant survival rate was 100% in both groups. The concentration of IFN-γ in PICF was significantly upregulated in Group 2 (p = .018). Furthermore, the IL-6 concentration was positively correlated with BOP% (p = .020).
CONCLUSIONS: Two-piece zirconia abutments exhibited superior technical performance compared to one-piece designs during a 3-year follow-up in the anterior region. However, further long-term research is necessary to verify the immunological stability of two-piece zirconia abutments.
METHODS: The study followed a split-mouth, double-blind, and randomized controlled clinical design for a duration of 3 years. Twenty-two eligible patients with 44 implants were randomly assigned to two groups: Group 1 (one-piece zirconia abutment with zirconia base, n = 22) and Group 2 (two-piece zirconia abutment with titanium base, n = 22). The primary outcome was the technical complication rate. Additionally, survival rates, cytokines concentrations in peri-implant crevicular fluid (PICF), peri-implant conditions, marginal bone loss, and pink/white esthetics score (PES/WES) were assessed as secondary outcomes.
RESULTS: Twelve of 22 patients attended the 1-year follow-up (due to the COVID pandemic), and 19 patients attended the 3-year examination. Two abutments in Group 1 were fractured after 10 and 12 months in function. Additionally, one screw loosening occurred in Group 1 at 1-year follow-up. The 3-year technical complication rate was significantly higher in Group 1 than that in Group 2 (15.79% vs. 0%, p < .001). The 3-year implant survival rate was 100% in both groups. The concentration of IFN-γ in PICF was significantly upregulated in Group 2 (p = .018). Furthermore, the IL-6 concentration was positively correlated with BOP% (p = .020).
CONCLUSIONS: Two-piece zirconia abutments exhibited superior technical performance compared to one-piece designs during a 3-year follow-up in the anterior region. However, further long-term research is necessary to verify the immunological stability of two-piece zirconia abutments.
摘要：
目的：比较临床，射线照相,一件式和两件式氧化锆基台之间的免疫学结果支持美学区域的单种植体冠。
方法：这项研究遵循张口，双盲,和随机对照临床设计，为期3年。将22例符合条件的44个植入物的患者随机分为两组：第1组（带有氧化锆基底的一体式氧化锆基台，n=22）和第2组（带有钛基的两件式氧化锆基台，n=22）。主要结果是技术并发症发生率。此外,存活率,种植体周围液（PICF）中的细胞因子浓度，种植体周围条件，边缘性骨丢失,粉红/白色美学评分(PES/WES)作为次要结局.
结果：22名患者中有12名参加了为期1年的随访（由于COVID大流行），19名患者参加了为期3年的检查。第1组的两个基牙在功能上10和12个月后断裂。此外,随访1年时,第1组出现1个螺钉松动.第1组的3年技术并发症发生率明显高于第2组（15.79％vs.0%,p<.001)。两组的3年植入物生存率均为100％。PICF中IFN-γ的浓度在第2组中显著上调(p=.018)。此外，IL-6浓度与BOP%呈正相关(p=0.020)。
结论：两片式氧化锆基台在前部区域进行了3年的随访期间，与单件式设计相比，表现出优越的技术性能。然而,需要进一步的长期研究来验证两件式氧化锆基台的免疫学稳定性。
方法：这项研究遵循张口，双盲,和随机对照临床设计，为期3年。将22例符合条件的44个植入物的患者随机分为两组：第1组（带有氧化锆基底的一体式氧化锆基台，n=22）和第2组（带有钛基的两件式氧化锆基台，n=22）。主要结果是技术并发症发生率。此外,存活率,种植体周围液（PICF）中的细胞因子浓度，种植体周围条件，边缘性骨丢失,粉红/白色美学评分(PES/WES)作为次要结局.
结果：22名患者中有12名参加了为期1年的随访（由于COVID大流行），19名患者参加了为期3年的检查。第1组的两个基牙在功能上10和12个月后断裂。此外,随访1年时,第1组出现1个螺钉松动.第1组的3年技术并发症发生率明显高于第2组（15.79％vs.0%,p<.001)。两组的3年植入物生存率均为100％。PICF中IFN-γ的浓度在第2组中显著上调(p=.018)。此外，IL-6浓度与BOP%呈正相关(p=0.020)。
结论：两片式氧化锆基台在前部区域进行了3年的随访期间，与单件式设计相比，表现出优越的技术性能。然而,需要进一步的长期研究来验证两件式氧化锆基台的免疫学稳定性。
