Abstract：
OBJECTIVE: The literature suggests that statins may increase superoxide dismutase (SOD) levels by different mechanisms. These effects may contribute to the antioxidant and anti-inflammatory effects of statins, which are thought to be beneficial in preventing cardiovascular events. However, there are also conflicting results concerning the effect of statins on SOD levels. The goal of this systematic review was to evaluate the effect of statin therapy on SOD activity.
METHODS: This systematic review was performed based on the PRISMA statement. The terms (\"statin\" or \"HMG-CoA reductase inhibitor\" OR \"lipid-lowering agents\" OR \"Atorvastatin\" OR \"Simvastatin\" OR \"Pravastatin\" OR \"Fluvastatin\" OR \"Lovastatin\") AND (\"superoxide dismutase\" OR \"SOD\" OR \"anti-oxidative\" OR \"oxidative stress\") were searched in database systems Google Scholar, PubMed/MEDLINE, and Scopus from inception to April 2022.
RESULTS: A total of 14 controlled clinical trials - 10 randomized and 4 non-randomized - were found to be eligible. Four studies measured SOD levels in plasma, six in serum, two in red blood cells, one in venous blood, and one on both red blood cells and venous blood matrices. Seven clinical trials used atorvastatin, six used simvastatin, and four used rosuvastatin. Six studies reported an increase in SOD activity, seven found no significant changes, and one showed a reduced SOD activity.
CONCLUSIONS: Our systematic review suggests that treatment with statins has a positive effect on SOD activity. However, evidence from further randomized controlled trials is required to confirm the potential antioxidant effect of statin therapy.
METHODS: This systematic review was performed based on the PRISMA statement. The terms (\"statin\" or \"HMG-CoA reductase inhibitor\" OR \"lipid-lowering agents\" OR \"Atorvastatin\" OR \"Simvastatin\" OR \"Pravastatin\" OR \"Fluvastatin\" OR \"Lovastatin\") AND (\"superoxide dismutase\" OR \"SOD\" OR \"anti-oxidative\" OR \"oxidative stress\") were searched in database systems Google Scholar, PubMed/MEDLINE, and Scopus from inception to April 2022.
RESULTS: A total of 14 controlled clinical trials - 10 randomized and 4 non-randomized - were found to be eligible. Four studies measured SOD levels in plasma, six in serum, two in red blood cells, one in venous blood, and one on both red blood cells and venous blood matrices. Seven clinical trials used atorvastatin, six used simvastatin, and four used rosuvastatin. Six studies reported an increase in SOD activity, seven found no significant changes, and one showed a reduced SOD activity.
CONCLUSIONS: Our systematic review suggests that treatment with statins has a positive effect on SOD activity. However, evidence from further randomized controlled trials is required to confirm the potential antioxidant effect of statin therapy.
摘要：
目的：文献表明他汀类药物可能通过不同的机制增加超氧化物歧化酶（SOD）水平。这些作用可能有助于他汀类药物的抗氧化和抗炎作用，被认为对预防心血管事件有益。然而,关于他汀类药物对SOD水平的影响也存在矛盾的结果。本系统综述的目的是评估他汀类药物治疗对SOD活性的影响。
方法：本系统综述基于PRISMA声明进行。术语（\"他汀类药物\"或\"HMG-CoA还原酶抑制剂\"或\"降脂药\"或\"阿托伐他汀\"或\"辛伐他汀\"或\"普伐他汀\"或\"氟伐他汀\"或\"洛伐他汀\"）和（\"超氧化物歧化酶\"或\"抗氧化\"或\"在Google数据库中搜索PubMed/MEDLINE,和Scopus从成立到2022年4月。
结果：共14项对照临床试验-10项随机和4项非随机-被发现是合格的。四项研究测量了血浆中的SOD水平，血清中有六个，两个红细胞，一个是静脉血，一个在红细胞和静脉血基质上。七项临床试验使用阿托伐他汀，六个用过的辛伐他汀，和四个使用瑞舒伐他汀。六项研究报告SOD活性增加，七个没有发现明显的变化，一个显示SOD活性降低。
结论：我们的系统评价表明，他汀类药物治疗对SOD活性有积极作用。然而,需要进一步的随机对照试验的证据来证实他汀类药物治疗的潜在抗氧化作用.
方法：本系统综述基于PRISMA声明进行。术语（\"他汀类药物\"或\"HMG-CoA还原酶抑制剂\"或\"降脂药\"或\"阿托伐他汀\"或\"辛伐他汀\"或\"普伐他汀\"或\"氟伐他汀\"或\"洛伐他汀\"）和（\"超氧化物歧化酶\"或\"抗氧化\"或\"在Google数据库中搜索PubMed/MEDLINE,和Scopus从成立到2022年4月。
结果：共14项对照临床试验-10项随机和4项非随机-被发现是合格的。四项研究测量了血浆中的SOD水平，血清中有六个，两个红细胞，一个是静脉血，一个在红细胞和静脉血基质上。七项临床试验使用阿托伐他汀，六个用过的辛伐他汀，和四个使用瑞舒伐他汀。六项研究报告SOD活性增加，七个没有发现明显的变化，一个显示SOD活性降低。
结论：我们的系统评价表明，他汀类药物治疗对SOD活性有积极作用。然而,需要进一步的随机对照试验的证据来证实他汀类药物治疗的潜在抗氧化作用.
