PDF(Pubmed)
Abstract：
The Semaphorin family is a group of proteins studied broadly for their functions in nervous systems. They consist of eight subfamilies ubiquitously expressed in vertebrates, invertebrates, and viruses and exist in membrane-bound or secreted forms. Emerging evidence indicates the relevance of semaphorins outside the nervous system, including angiogenesis, cardiogenesis, osteoclastogenesis, tumour progression, and, more recently, the immune system. This review provides a broad overview of current knowledge on the role of semaphorins in the immune system, particularly its involvement in inflammatory and infectious diseases, including chlamydial infections.
摘要：
信号素家族是一组广泛研究其在神经系统中的功能的蛋白质。它们由八个在脊椎动物中普遍表达的亚家族组成，无脊椎动物,和病毒，以膜结合或分泌形式存在。新出现的证据表明信号在神经系统外的相关性，包括血管生成,心脏发生，破骨细胞生成，肿瘤进展，and,最近,免疫系统。这篇综述提供了有关信号素在免疫系统中的作用的当前知识的广泛概述，特别是它参与炎症和传染病，包括衣原体感染.
