%0 Journal Article
%T Semaphorins in immune cell function, inflammatory and infectious diseases.
%A Thomas R
%A Yang X
%J Curr Res Immunol
%V 4
%N 0
%D 2023
%M 37645659
暂无%R 10.1016/j.crimmu.2023.100060
%X The Semaphorin family is a group of proteins studied broadly for their functions in nervous systems. They consist of eight subfamilies ubiquitously expressed in vertebrates, invertebrates, and viruses and exist in membrane-bound or secreted forms. Emerging evidence indicates the relevance of semaphorins outside the nervous system, including angiogenesis, cardiogenesis, osteoclastogenesis, tumour progression, and, more recently, the immune system. This review provides a broad overview of current knowledge on the role of semaphorins in the immune system, particularly its involvement in inflammatory and infectious diseases, including chlamydial infections.