Abstract：
Biofilms formed by pathogenic or spoilage microorganisms have become serious issues in the dairy industry, as this mode of life renders such microorganisms highly resistant to cleaning-in-place (CIP) procedures, disinfectants, desiccation, and other control strategies. The advent of omics techniques, especially the integration of different omics tools, has greatly improved our understanding of the features of microbial biofilms, and provided in-depth knowledge on developing effective methods that are directly against deleterious biofilms. This review provides novel insights into the single use of each omics tool and the application of multiomics tools to unravel the mechanisms of biofilm formation, specific molecular phenotypes exhibited by biofilms, and biofilm control strategies. Challenges and future perspective on the integration of omics tools for biofilm studies are also addressed.
摘要：
致病微生物或腐败微生物形成的生物膜已成为乳制品行业中的严重问题，因为这种生活方式使这种微生物对就地清洁（CIP）程序具有高度抵抗力，消毒剂,干燥,和其他控制策略。组学技术的出现，特别是不同组学工具的整合，大大提高了我们对微生物生物膜特征的理解，并提供了有关开发直接对抗有害生物膜的有效方法的深入知识。这篇综述提供了对每种组学工具的单一使用以及多组学工具在揭示生物膜形成机制方面的应用的新颖见解。生物膜表现出的特定分子表型，和生物膜控制策略。还讨论了整合用于生物膜研究的组学工具的挑战和未来观点。
