PDF(Pubmed)
Abstract：
The global threat of neglected tropical diseases (NTDs) constitutes a public health issue in underdeveloped countries. Zoonotic helminthiases are the most common human NTD agents in developing countries in sub-Saharan Africa, Asia, and the Americas, causing a global burden of disease that exceeds that of more recognized infectious diseases such as malaria and tuberculosis. Wild canids are well-known mammals that act as natural reservoirs of zoonotic-relevant helminthiasis worldwide, thus playing a pivotal role in their epidemiology and transmission to humans. Here we evaluate the occurrence of zoonotic gastrointestinal helminths in two Neotropical wild canid species from the Amazonian and Andean regions of Colombia, i.e., the bush dog (Speothos venaticus) and the crab-eating fox (Cerdocyon thous). We recovered tapeworm proglottids from bush dog fecal samples and identified them molecularly as the canine-specific lineage of Dipylidium caninum by using cytochrome c oxidase subunit I (cox1) gene sequences. Moreover, examination of a crab-eating fox during necropsy revealed the presence of non-embryonated eggs of the neglected nematode Lagochilascaris cf. minor, in addition to eggs and gravid proglottids of the cestode Spirometra mansoni. These findings represent the first report of zoonotic-relevant cestodes, i.e., D. caninum (\"canine genotype\"), S. mansoni, and the nematode L. cf. minor, in bush dogs and crab-eating foxes as final hosts. The occurrence of these zoonotic helminthiases in wild canid species calls for regular monitoring programs to better understand the epidemiology and transmission routes of neglected dipylidiasis, lagochilascariosis, and sparganosis in South America.
摘要：
被忽视的热带病（NTD）的全球威胁构成了不发达国家的公共卫生问题。人畜共患病蠕虫酶是撒哈拉以南非洲发展中国家最常见的人类NTD病原体，亚洲,和美洲，造成的全球疾病负担超过了更多公认的传染病，如疟疾和结核病。野生犬科动物是众所周知的哺乳动物，它们是全世界人畜共患相关蠕虫病的天然水库，因此在其流行病学和向人类传播中起着关键作用。在这里，我们评估了来自哥伦比亚亚马逊和安第斯地区的两种新热带野生犬科动物中人畜共患胃肠道蠕虫的发生，即，丛林狗（Speothosvenaticus）和食蟹狐狸（Cerdocyonthous）。我们从灌木犬粪便样品中回收了tape虫的proglottis虫，并通过使用细胞色素c氧化酶亚基I（cox1）基因序列将其分子鉴定为犬Dipylidium犬的犬特异性谱系。此外，尸检期间对食蟹狐狸的检查显示，存在被忽视的线虫Lagochilascaris的非胚胎卵。未成年人,除了食蟹猴Spirometramansoni的卵和妊娠前。这些发现代表了与人畜共患有关的昆虫的第一份报告，即，D.犬（“犬基因型”），S.Mansoni,和线虫L.cf.未成年人,在丛林狗和食蟹狐狸中作为最终宿主。这些人畜共患蠕虫病毒在野生犬科动物中的发生需要定期监测计划，以更好地了解被忽视的龙线虫病的流行病学和传播途径，lagochilascariosis,南美的裂头虫病。
