PDF(Pubmed)
Abstract：
The ADRB3 gene plays a role in energy expenditure by participating in lipolysis, which affects body composition and performance. The ADRB3 rs4994 polymorphism has been studied in groups of athletes, overweight individuals, and obese and diabetic patients, but it has not been studied in young and healthy adults so far. In the present study, we examined the association of ADRB3 rs4994 polymorphism with body composition, somatotype, cardiorespiratory fitness and physical activity in young, healthy adults (N = 304). All subjects had anthropometric measurements, and somatotypes were assessed using the Heath-Carter method. In addition, cardiorespiratory fitness and physical activity levels were assessed. Genotyping for the ADRB3 gene was performed using a PCR-RFLP method. In the male group, body components were associated with the Trp64Trp genotype (waist circumference (p = 0.035), hip circumference (p = 0.029), BF (%) (p = 0.008), and BF (kg) (p = 0.010), BMI (p = 0.005), WHtR (p = 0.021), and BAI (p = 0.006)). In addition, we observed that the Trp64Trp genotype was associated with somatotype components (p = 0.013). In contrast, the Arg allele was associated with the ectomorphic components (0.006). We also observed a positive impact of the Trp64Trp genotype with maximal oxygen uptake (p= 0.023) and oxygen pulse (p = 0.024). We observed a negative relationship of the Trp64Trp genotype in the female group with reported moderate-intensity exercise (p = 0.036). In conclusion, we found an association of the Trp64 allele with anthropometric traits, somatotype and parameters describing physical performance in the male group. In the female subpopulation, we only found an effect of the polymorphism Trp64Arg on the level of physical activity for moderate-intensity exercise.
摘要：
ADRB3基因通过参与脂肪分解在能量消耗中发挥作用，影响身体成分和性能。ADRB3rs4994多态性已经在运动员群体中进行了研究，超重个体,肥胖和糖尿病患者，但是到目前为止，还没有在年轻健康的成年人身上进行过研究。在本研究中,我们检查了ADRB3rs4994多态性与身体成分的关联，体型,年轻人的心肺健康和身体活动，健康成人（N=304）。所有受试者都进行了人体测量，和体型使用Heath-Carter方法进行评估。此外,评估心肺适应性和体力活动水平.使用PCR-RFLP方法进行ADRB3基因的基因分型。在男性群体中，身体成分与Trp64Trp基因型相关(腰围(p=0.035)，臀围（p=0.029），BF（%）（p=0.008），和BF(kg)(p=0.010)，BMI（p=0.005），WHtR(p=0.021),和BAI(p=0.006))。此外,我们观察到Trp64Trp基因型与体型成分相关(p=0.013).相比之下,Arg等位基因与异位成分相关(0.006)。我们还观察到Trp64Trp基因型对最大摄氧量（p=0.023）和氧脉冲（p=0.024）的积极影响。我们观察到女性组中Trp64Trp基因型与报道的中等强度运动呈负相关（p=0.036）。总之,我们发现Trp64等位基因与人体测量特征有关联，描述男性组身体表现的体型和参数。在女性亚群中，我们仅发现Trp64Arg多态性对中等强度运动的身体活动水平有影响。
