引言近年来,运动已越来越被认为是一种有效且有前景的非药物干预措施,可改善帕金森病(PD)患者的身体功能。心肺健身(CRF)是衡量一个人进行有氧运动能力的客观指标。因此,有必要评估PD患者的CRF。然而,中国PD患者的CRF缺乏。本研究是通过在固定周期测功机上进行心肺运动试验(CPET)来评估早中期PD患者的心肺适应性;方法:比较两组受试者之间CPET各指标的差异;一般数据如疾病持续时间,还收集了药物使用和运动习惯。结果:1)最后,36名PD患者和12名健康对照者成功完成了CPET,没有任何不良事件。2)V'O2峰,Metspeak,重申,MVVpeak,Wspeak,HRpeak,HRpeak/pre,HRR-1分钟衰减的百分比>12bpm,PD组SBP峰低于对照组(均p<0.05)。详细数据:V'O2峰(15.7±4.5vs21.5±3.6ml/kg/min,p<0.01),Metspeak(4.5±1.3vs6.1±1.0,p<0.01),RERpeak(1.04±0.10vs1.15±0.10,p=0.001),MVVpeak(37.22±11.58vs53.00±16.85L/min,p=0.009),Wpeak(49.17±29.72vs49.17±29.72W,p<0.01),HRpeak(111.08±16.67vs111.08±16.67bpm,p<0.01),HRpeak/pre(71.19±10.06vs96.00±21.13,p=0.002),HRR-1min衰减百分比>12bpm(33.3%vs100%,p<0.01),SBP(155.81±31.83vs175.83±17.84mmHg,p=0.01)。3)将PD患者分为高V'O2峰组(V'O2峰≥15mL/kg/min)和低V'O2峰组(V'O2峰<15mL/kg/min)。病人的年龄,高V/O2峰组的Hoehn-Yahr分级和症状波动发生率较低(分别为p<0.05),男性的百分比和HRR-1分钟衰减>12bpm的百分比更高(分别为p<0.05);p<0.05被认为是统计学上的显着差异。详细数据:患者年龄(61.05±6.93vs68.57±7.99岁,p=0.005),Hoehn-Yahr等级(1.75±0.48vs2.18±0.64,p=0.028),症状波动发生率(59.1vs92.9%,p=0.03),男性百分比(77.7比42.9%,p=0.041),HRR-1分钟衰减的百分比>12bpm(50vs7.1%,p=0.008)。结论:早中期帕金森病患者行CPET是安全的,心肺适应性明显降低。PD患者对运动试验的HR和SBP反应减弱。雌性,年龄较大,波动的症状,高H-Y分期,较高的ADL可能与较低的摄氧量有关。
UNASSIGNED: To evaluate cardiorespiratory fitness in patients with early to mid-stage Parkinson\'s disease by cardiopulmonary exercise test (CPET) on a stationary cycle ergometer.
UNASSIGNED: To compare the differences in each index of the cardiopulmonary exercise test between the two groups of subjects; general data such as disease duration, medication use and exercise habits were also collected.
UNASSIGNED: (1) Finally, 36 Parkinson\'s disease patients and 12 healthy controls successfully completed the cardiopulmonary exercise test without any adverse events. (2) The V\'O2peak, Metspeak, RERpeak, MVVpeak, Wpeak, HRpeak, HRpeak/pre, percentage of HRR-1 min decay > 12 bpm, SBPpeak in the Parkinson\'s disease group were lower than those in the control group (p < .05, each). Detailed data: V\'O2peak (15.7 ± 4.5vs21.5 ± 3.6 ml/kg/min, p < .01), Metspeak (4.5 ± 1.3 vs 6.1 ± 1.0, p < .01), RERpeak (1.04 ± 0.10 vs 1.15 ± 0.10, p = .001), MVVpeak (37.22 ± 11.58 vs 53.00 ± 16.85L/min, p = .009), Wpeak (49.17 ± 29.72 vs 49.17 ± 29.72W, p < .01), HRpeak (111.08 ± 16.67 vs 111.08 ± 16.67bpm, p < .01), HRpeak/pre (71.19 ± 10.06 vs 96.00 ± 21.13, p = .002), percentage of HRR-1min decay > 12bpm (33.3% vs 100%, p < .01), systolic blood pressure (155.81 ± 31.83 vs 175.83 ± 17.84 mmHg, p = .01). (3) Divided Parkinson\'s disease patients into high V\'O2peak group (V\'O2peak ≥ 15 mL/kg/min) and low V\'O2peak group (V\'O2peak < 15 mL/kg/min). The age of patients, Hoehn-Yahr grade and incidence of symptom fluctuation in high V\'O2peak group were lower (p < .05, respectively), percentage of males and percentage of HRR-1 min decay > 12 bpm were higher (p < .05, respectively); p < .05 is considered a statistically significant difference. Detailed data: age of patients(61.05 ± 6.93 vs 68.57 ± 7.99 years, p = .005), Hoehn-Yahr grade(1.75 ± 0.48 vs 2.18 ± 0.64, p = .028), incidence of symptom fluctuation (59.1 vs 92.9%, p = .03), percentage of males (77.7 vs 42.9%, p = .041), percentage of HRR-1 min decay > 12 bpm (50 vs 7.1%, p = .008).
UNASSIGNED: Cardiopulmonary exercise test was safe to perform and the cardiorespiratory fitness is significantly reduced in patients with early and middle stage Parkinson\'s disease. Patients with Parkinson\'s disease presented blunted heart rate and systolic blood pressure responses to exercise test. Females, older age, fluctuating symptoms, high H-Y staging and higher activities of daily living may be associated with lower oxygen uptake.