Abstract：
OBJECTIVE: To compare long-term real-world outcomes of corneal thickness (CT) alterations in proliferative diabetic retinopathy (PDR) patients treated with panretinal photocoagulation (PRP) and intravitreal conbercept (IVC).
METHODS: This retrospective study included 69 eyes of 69 patients with PDR (42 PRP and 27 IVC). Full corneal thickness (FCT), corneal epithelial thickness (CET) and corneal stromal thickness (CST) measured by anterior segment optical coherence tomography at baseline were compared between groups. These CT changes at last follow-up from baseline were also compared between groups and within each group.
RESULTS: During a mean follow-up of more than two years, the IVC group demonstrated a significantly increased corneal thickness from baseline compared to the PRP group in some areas (PRP vs. IVC: FCT 0-2 mm: -0.59 ± 9.31 vs. 5.59 ± 9.23 μm, p = 0.009; CST 0-2 mm: -2.05 ± 8.79 vs. 3.48 ± 7.52 μm, p = 0.015; CST 2-5 mm: -1.78 ± 13.27 vs. 5.68 ± 14.53 μm, p = 0.046). In within-group comparisons, a significantly increased FCT from baseline was found in the 0-2 mm area in the IVC group (p = 0.004), but no significant change was observed in the PRP group (p = 0.691). For CET changes, a significantly increased CT was observed in the 0-2 mm, 2-5 mm and 5-7 mm areas in both groups respectively (all p < 0.05). Regarding CST, an increased CT was found in the 0-2 mm area in the IVC group (p = 0.037), while a decreased trend was observed in 0-2 mm and 2-5 mm areas in the PRP group (all p > 0.05).
CONCLUSIONS: When using PRP or IVC in the long-term management of PDR, CT changes should be considered. This may provide evidence for corneal protection during PDR treatment.
METHODS: This retrospective study included 69 eyes of 69 patients with PDR (42 PRP and 27 IVC). Full corneal thickness (FCT), corneal epithelial thickness (CET) and corneal stromal thickness (CST) measured by anterior segment optical coherence tomography at baseline were compared between groups. These CT changes at last follow-up from baseline were also compared between groups and within each group.
RESULTS: During a mean follow-up of more than two years, the IVC group demonstrated a significantly increased corneal thickness from baseline compared to the PRP group in some areas (PRP vs. IVC: FCT 0-2 mm: -0.59 ± 9.31 vs. 5.59 ± 9.23 μm, p = 0.009; CST 0-2 mm: -2.05 ± 8.79 vs. 3.48 ± 7.52 μm, p = 0.015; CST 2-5 mm: -1.78 ± 13.27 vs. 5.68 ± 14.53 μm, p = 0.046). In within-group comparisons, a significantly increased FCT from baseline was found in the 0-2 mm area in the IVC group (p = 0.004), but no significant change was observed in the PRP group (p = 0.691). For CET changes, a significantly increased CT was observed in the 0-2 mm, 2-5 mm and 5-7 mm areas in both groups respectively (all p < 0.05). Regarding CST, an increased CT was found in the 0-2 mm area in the IVC group (p = 0.037), while a decreased trend was observed in 0-2 mm and 2-5 mm areas in the PRP group (all p > 0.05).
CONCLUSIONS: When using PRP or IVC in the long-term management of PDR, CT changes should be considered. This may provide evidence for corneal protection during PDR treatment.
摘要：
目的：比较全视网膜光凝（PRP）和玻璃体内康柏西普（IVC）治疗的增殖性糖尿病视网膜病变（PDR）患者角膜厚度（CT）改变的长期现实结果。
方法：这项回顾性研究包括69例PDR患者（42例PRP和27例IVC）的69只眼。全角膜厚度（FCT），比较各组角膜上皮厚度(CET)和角膜基质厚度(CST)。最后一次随访时从基线开始的这些CT变化也在组间和各组内进行比较。
结果：在超过两年的平均随访中，在某些区域，与PRP组相比，IVC组显示出与基线相比的角膜厚度显着增加（PRP与IVC：FCT0-2mm：-0.59±9.31vs.5.59±9.23μm,p=0.009；CST0-2mm：-2.05±8.79vs.3.48±7.52μm,p=0.015；CST2-5mm：-1.78±13.27vs.5.68±14.53μm,p=0.046)。在组内比较中，在IVC组的0-2mm区域中发现FCT从基线显着增加（p=0.004），但PRP组无明显变化(p=0.691).对于CET的改变,在0-2毫米处观察到CT显着增加，两组分别为2-5mm和5-7mm区域（均p<0.05）。关于CST，IVC组的0-2mm区域CT增加（p=0.037），而PRP组的0-2mm和2-5mm区域呈下降趋势（均p>0.05）。
结论：在PDR的长期管理中使用PRP或IVC时，应考虑CT改变。这可能为PDR治疗期间的角膜保护提供证据。
方法：这项回顾性研究包括69例PDR患者（42例PRP和27例IVC）的69只眼。全角膜厚度（FCT），比较各组角膜上皮厚度(CET)和角膜基质厚度(CST)。最后一次随访时从基线开始的这些CT变化也在组间和各组内进行比较。
结果：在超过两年的平均随访中，在某些区域，与PRP组相比，IVC组显示出与基线相比的角膜厚度显着增加（PRP与IVC：FCT0-2mm：-0.59±9.31vs.5.59±9.23μm,p=0.009；CST0-2mm：-2.05±8.79vs.3.48±7.52μm,p=0.015；CST2-5mm：-1.78±13.27vs.5.68±14.53μm,p=0.046)。在组内比较中，在IVC组的0-2mm区域中发现FCT从基线显着增加（p=0.004），但PRP组无明显变化(p=0.691).对于CET的改变,在0-2毫米处观察到CT显着增加，两组分别为2-5mm和5-7mm区域（均p<0.05）。关于CST，IVC组的0-2mm区域CT增加（p=0.037），而PRP组的0-2mm和2-5mm区域呈下降趋势（均p>0.05）。
结论：在PDR的长期管理中使用PRP或IVC时，应考虑CT改变。这可能为PDR治疗期间的角膜保护提供证据。
