Abstract：
The COVID-19 (coronavirus disease 2019) pandemic\'s steady condition coupled with predominance of emerging contaminants in the environment and its synergistic implications in recent times has stoked interest in combating medical emergencies in this dynamic environment. In this context, high concentrations of pharmaceutical and personal care products (PPCPs), microplastics (MPs), antimicrobial resistance (AMR), and soaring coinfecting microbes, tied with potential endocrine disruptive (ED) are critical environmental concerns that requires a detailed documentation and analysis. During the pandemic, the identification, enumeration, and assessment of potential hazards of PPCPs and MPs and (used as anti-COVID-19 agents/applications) in aquatic habitats have been attempted globally. Albeit receding threats in the magnitude of COVID-19 infections, both these pollutants have still posed serious consequences to aquatic ecosystems and the very health and hygiene of the population in the vicinity. The surge in the contaminants post-COVID also renders them to be potent vectors to harbor and amplify AMR. Pertinently, the present work attempts to critically review such instances to understand the underlying mechanism, interactions swaying the current health of our environment during this post-COVID-19 era. During this juncture, although prevention of diseases, patient care, and self-hygiene have taken precedence, nevertheless antimicrobial stewardship (AMS) efforts have been overlooked. Unnecessary usage of PPCPs and plastics during the pandemic has resulted in increased emerging contaminants (i.e., active pharmaceutical ingredients and MPs) in various environmental matrices. It was also noticed that among COVID-19 patients, while the bacterial co-infection prevalence was 0.2-51%, the fungi, viral, protozoan and helminth were 0.3-49, 1-22, 2-15, 0.4-15% respectively, rendering them resistant to residual PPCPs. There are inevitable chances of ED effects from PPCPs and MPs applied previously, that could pose far-reaching health concerns. Furthermore, clinical and other experimental evidence for many newer compounds is very scarce and demands further research. Pro-active measures targeting effective waste management, evolved environmental policies aiding strict regulatory measures, and scientific research would be crucial in minimizing the impact and creating better preparedness towards such events among the masses fostering sustainability.
摘要：
COVID-19(2019年冠状病毒病)大流行不仅激发了人们对研究其造成的技术经济危机的兴趣，还激发了人们对研究这种医疗紧急情况对我们环境造成的影响的兴趣。已尝试严格审查环境问题的不同方面的详细概述，例如药品和个人护理产品（PPCP）水平升高，增加抗菌素耐药性（AMR），大量的废物和微塑料，越来越多的共感染微生物，以及潜在的内分泌干扰(ED)效应，以了解后COVID-19时代我们环境的当前健康状况。大流行导致环境中这些污染物的水平升高，进一步充当AMR增强的载体。作为疾病的预防,病人护理,自我卫生优先，抗菌药物管理(AMS)的努力已被推迟。人们注意到，在COVID-19患者中，细菌的流行，真菌,其他病毒,原生动物,蠕虫占0.2-51%,0.3-49%，1-22%,2-15%,&0.4-15%，分别。这样的共感染微生物可以对残留的PPCP具有抗性。Further,许多新化合物的临床和其他实验证据非常缺乏，需要进一步研究。我们的综述简要表明：i)合并感染的误诊，恐惧驱动的PPCP库存加剧了这个问题。ii）COVID-19后，抗菌素耐药性和内分泌破坏性化学物质有所增加。iii）生活方式的变化，例如增加在线购物，包装食品导致了更多的塑料垃圾。iv）AI/ML的使用对于预测COVID相关废物即将到来的威胁建模是必要的。and,v)需要对与AMR峰值相关的未来伤亡进行新的估计，EDC,和PPCPs。我们推荐AMS,有效的废物管理，政府和监管框架，加强科学研究，以尽量减少影响，并为COVID-19等事件做好准备。
