PDF(Pubmed)
Abstract：
Invasive meningococcal disease (IMD) is an uncommon but serious and potentially fatal condition, mainly affecting infants. In 2017, Argentina introduced a vaccination program against serogroups A, C, W and Y (MenACWY) for infants aged 3, 5 and 15 months and adolescents aged 11 years. The objective of this study was to review the burden of IMD in Argentina in 2010-2019. Data were obtained from national surveillance databases, and the study estimated IMD incidence, mortality, case-fatality rates, and serogroup distributions across age groups. A total of 1,972 IMD cases were reported in the study period, with the highest incidence in infants aged < 1 year. Incidence peaked in 2013 and subsequently declined. Mortality rates were 18 times higher in infants than in other age groups, reflecting the high impact of IMD in this age group. The case-fatality rate was 8.5% on average and increased with age. The proportion of notified cases with serogroup identification increased over the period, reaching 91% in 2019. The most common serogroups over the study period were serogroup B (48%) and serogroup W (42%), with an increase in B relative to W since 2015. In infants aged < 1 year, the proportion of serogroup B increased in recent years, reaching around 70% of characterized cases in 2018-2019. These results show the dynamism of IMD and indicate the importance of vaccination at an early age and offering protection against predominant serogroups. These data are valuable to support evidence-based decision-making in healthcare.
摘要：
侵袭性脑膜炎球菌病（IMD）是一种罕见但严重且可能致命的疾病，主要影响婴儿。2017年，阿根廷推出了针对血清群A的疫苗接种计划，C,W和Y（MenACWY）适用于3、5和15个月的婴儿和11岁的青少年。这项研究的目的是回顾2010-2019年阿根廷IMD的负担。数据来自国家监测数据库，这项研究估计了IMD的发病率，死亡率,病死率,和各年龄组的血清群分布。在研究期间共报告了1,972例IMD病例，年龄<1岁的婴儿发病率最高。发病率在2013年达到顶峰，随后下降。婴儿的死亡率比其他年龄组高18倍，反映了IMD在这个年龄段的高影响。病死率平均为8.5％，并随年龄增长而增加。在此期间，具有血清群识别的通报病例比例有所增加，2019年达到91%。研究期间最常见的血清群是血清群B（48%）和血清群W（42%）。自2015年以来，B相对于W有所增加。1岁以下的婴儿，血清B组的比例近年来有所增加，在2018-2019年达到约70%的特征性病例。这些结果表明了IMD的活力，并表明了在早期接种疫苗并提供针对主要血清群的保护的重要性。这些数据对于支持医疗保健中基于证据的决策很有价值。
