PDF(Pubmed)
Abstract：
There is strong evidence that substance use is a risk factor for suicidality. Prior studies have focused on the suicide risk associated with using individual substances, even though substance users often use more than one substance. This study investigates the association between patterns of adolescent substance use and suicidality in young adulthood.
Participants were U.S. adolescents (n = 2,111, 58.9% female, mean age = 16.31 years) from the NEXT Generation Health Study, which followed tenth graders for 7 years (2009/2010-2016) and collected data via yearly surveys. Longitudinal latent class analysis was used to identify high school patterns of substance use, and logistic regression was used to relate these patterns to risk of suicidality in young adulthood.
We identified two groups of adolescents: \"non-/infrequent users\" (71%) and \"multiple substance users\" (29%). Multiple substance users had higher odds of making a suicide plan or attempt in young adulthood (odds ratio [OR] = 2.41, 95% CI [1.05, 5.53]), but not suicidal ideation (OR = 1.55, 95% CI [0.80, 2.99]), than non-/infrequent users, adjusting for sociodemographic factors and depressive symptoms. Multiple substance users with suicidal ideation were not more likely to progress to a later plan or attempt (OR = 1.41, 95% CI [0.41, 4.84]) than non-/infrequent users.
Adolescents who use substances in high school are at higher risk for making a suicide plan or attempt in young adulthood. Early identification of these adolescents may help inform interventions to mitigate risk for suicidal behaviors in young adulthood.
Participants were U.S. adolescents (n = 2,111, 58.9% female, mean age = 16.31 years) from the NEXT Generation Health Study, which followed tenth graders for 7 years (2009/2010-2016) and collected data via yearly surveys. Longitudinal latent class analysis was used to identify high school patterns of substance use, and logistic regression was used to relate these patterns to risk of suicidality in young adulthood.
We identified two groups of adolescents: \"non-/infrequent users\" (71%) and \"multiple substance users\" (29%). Multiple substance users had higher odds of making a suicide plan or attempt in young adulthood (odds ratio [OR] = 2.41, 95% CI [1.05, 5.53]), but not suicidal ideation (OR = 1.55, 95% CI [0.80, 2.99]), than non-/infrequent users, adjusting for sociodemographic factors and depressive symptoms. Multiple substance users with suicidal ideation were not more likely to progress to a later plan or attempt (OR = 1.41, 95% CI [0.41, 4.84]) than non-/infrequent users.
Adolescents who use substances in high school are at higher risk for making a suicide plan or attempt in young adulthood. Early identification of these adolescents may help inform interventions to mitigate risk for suicidal behaviors in young adulthood.
摘要：
目的：有强有力的证据表明药物使用是自杀的危险因素。先前的研究集中在与使用单个物质相关的自杀风险，即使物质使用者经常使用一种以上的物质。这项研究调查了青少年物质使用模式与成年后自杀行为之间的关系。
方法：参与者为美国青少年（n=2111，58.9％为女性，平均年龄=16.31岁）来自下一代健康研究，该研究对十年级学生进行了7年（2009/2010-2016年），并通过年度调查收集了数据。纵向潜在类别分析用于确定高中的物质使用模式，而逻辑回归用于将这些模式与成年后的自杀风险联系起来。
结果：我们确定了两组青少年：“非/不经常使用者”（71％），和“多物质用户”（29%）。多物质使用者在年轻时制定自杀计划或尝试自杀的几率更高（OR=2.41，95％CI[1.05，5.53]），但不是自杀意念(OR=1.55，95%CI[0.80，2.99])，比调整社会人口统计学因素和抑郁症状的非/不经常用户。有自杀意念的多物质使用者比非/不经常使用者更不可能进展到以后的计划或尝试(OR=1.41,95%CI[0.41,4.84])。
结论：在高中时期使用药物的青少年在青少年时期制定自杀计划或尝试自杀的风险较高。这些青少年的早期识别可能有助于提供干预措施，以减轻年轻成年期自杀行为的风险。
方法：参与者为美国青少年（n=2111，58.9％为女性，平均年龄=16.31岁）来自下一代健康研究，该研究对十年级学生进行了7年（2009/2010-2016年），并通过年度调查收集了数据。纵向潜在类别分析用于确定高中的物质使用模式，而逻辑回归用于将这些模式与成年后的自杀风险联系起来。
结果：我们确定了两组青少年：“非/不经常使用者”（71％），和“多物质用户”（29%）。多物质使用者在年轻时制定自杀计划或尝试自杀的几率更高（OR=2.41，95％CI[1.05，5.53]），但不是自杀意念(OR=1.55，95%CI[0.80，2.99])，比调整社会人口统计学因素和抑郁症状的非/不经常用户。有自杀意念的多物质使用者比非/不经常使用者更不可能进展到以后的计划或尝试(OR=1.41,95%CI[0.41,4.84])。
结论：在高中时期使用药物的青少年在青少年时期制定自杀计划或尝试自杀的风险较高。这些青少年的早期识别可能有助于提供干预措施，以减轻年轻成年期自杀行为的风险。
