Abstract：
Purpose: Treatment-related sexual problems are common, but understudied, among survivors of Childhood, Adolescent, and Young Adult Cancer Survivors (CAYACS). We investigated awareness of, and information needs regarding, sexual problems as late effects in a nation-wide sample of long-term CAYACS. Methods: Five-year survivors were identified by the Cancer Registry of Norway, diagnosed between 1985 and 2009 with any childhood cancer (0-18 years of age, excluding central nervous system tumors), leukemia, colorectal cancer, breast cancer, non-Hodgkin lymphoma, or malignant melanoma (19-39 years of age). Malignant melanoma survivors treated with local surgery only served as an unmatched reference group. Survivors were mailed a survey, including items on awareness and information needs. Descriptive statistics and logistic regression analyses were used for data analyses. Results: Of 5361 CAYACS invited, 2104 responded (39%), of which 1870 were eligible for inclusion. In all, 62% were aware of sexual problems as late effects (46% aware only, 16% experienced it) and 31% reported information needs. Of all groups, childhood cancer survivors reported the lowest level of awareness (43% aware, 7% experienced it) and the highest information needs (38%). In multivariable models, awareness was associated with higher education, shorter time since treatment, more intense treatments, and experiencing hormonal changes and reduced fertility. Information needs were associated with having experienced sexual problems, female gender, higher treatment intensity, chronic fatigue, and increased depressive symptoms. Conclusions: A substantial proportion of long-term CAYACS report being unaware of, and have information needs regarding sexual problems as late effects decades beyond treatment. Addressing such issues during follow-up care is important.
摘要：
目的：治疗相关的性问题很常见，但研究不足,在童年的幸存者中，青少年,年轻的成人癌症幸存者（CAYACS）。我们调查了，和信息需求，性问题在全国范围的长期CAYACS样本中作为晚期影响。方法：挪威癌症登记处确定了五年的幸存者，在1985年至2009年之间诊断出患有任何儿童癌症(0-18岁，排除中枢神经系统肿瘤)，白血病,结直肠癌,乳腺癌,非霍奇金淋巴瘤,或恶性黑色素瘤（19-39岁）。用局部手术治疗的恶性黑色素瘤幸存者仅作为无与伦比的参照组。幸存者收到了一份调查，包括关于意识和信息需求的项目。描述性统计和逻辑回归分析用于数据分析。结果：在5361个CAYACS邀请中，2104人回答（39%），其中1870年有资格列入。总之,62%的人意识到性问题是晚期影响(46%的人只意识到，16%的人经历过)和31%的人报告了信息需求。在所有团体中，儿童癌症幸存者报告的知晓率最低(43%的人意识到，7％的人经历了它）和最高的信息需求（38％）。在多变量模型中，意识与高等教育有关，治疗后的时间较短，更激烈的治疗，经历荷尔蒙变化和生育能力下降。信息需求与经历过的性问题有关，女性性别,更高的治疗强度，慢性疲劳,增加抑郁症状。结论：相当大比例的长期CAYACS报告不知道，并有关于性问题的信息需求，作为治疗后几十年的晚期影响。在后续护理中解决这些问题很重要。
