Abstract：
Aquagenic wrinkling of palms (AWP) is emerging as a screening test for cystic fibrosis (CF). There is lack of normative data for the same in our population.
To generate normative data for AWP in children 1-15 years of age and to describe the factors associated with it.
Children aged 1-15 years were enrolled after obtaining informed consent and assent of the parent and child based on age. Information regarding age, gender, anthropometry, indications for visiting hospital and drug intake were noted down. Wrinkling test was done using distilled water maintained in room temperature. Sweat chloride analysis was done using Nano duct sweat analysis system for children having AWP within 3 min. The mean/median time to wrinkle was noted and presented as centile curves after smoothing.
The mean (SD) and median (interquartile range [IQR]) aquagenic wrinkling time in children 1-15 years of age was 4.88 (1.066) and 5 (4-5.75) minutes respectively. The mean (SD) and median (IQR) time for AWP was 4.78 (1.076) and 5 (4-5) minutes respectively for boys and 4.98 (1.048) and 5 (4-6) minutes, respectively for girls. The time taken to wrinkle was observed to increase with age. Males have earlier AWP than females. There was no association between AWP and anthropometry or sweat chloride levels.
We have estimated the normative data for AWP in children 1-15 years of age which can be used for CF screening in children with typical clinical features from resource limited settings.
To generate normative data for AWP in children 1-15 years of age and to describe the factors associated with it.
Children aged 1-15 years were enrolled after obtaining informed consent and assent of the parent and child based on age. Information regarding age, gender, anthropometry, indications for visiting hospital and drug intake were noted down. Wrinkling test was done using distilled water maintained in room temperature. Sweat chloride analysis was done using Nano duct sweat analysis system for children having AWP within 3 min. The mean/median time to wrinkle was noted and presented as centile curves after smoothing.
The mean (SD) and median (interquartile range [IQR]) aquagenic wrinkling time in children 1-15 years of age was 4.88 (1.066) and 5 (4-5.75) minutes respectively. The mean (SD) and median (IQR) time for AWP was 4.78 (1.076) and 5 (4-5) minutes respectively for boys and 4.98 (1.048) and 5 (4-6) minutes, respectively for girls. The time taken to wrinkle was observed to increase with age. Males have earlier AWP than females. There was no association between AWP and anthropometry or sweat chloride levels.
We have estimated the normative data for AWP in children 1-15 years of age which can be used for CF screening in children with typical clinical features from resource limited settings.
摘要：
背景：手掌的水生性皱纹（AWP）正在成为囊性纤维化（CF）的筛查测试。我国人口中缺乏同样的规范数据。
目的：生成1-15岁儿童AWP的规范数据，并描述与之相关的因素。
方法：1-15岁的儿童在获得父母和儿童的知情同意并根据年龄进行登记。关于年龄的信息，性别,人体测量学,记录了访问医院和药物摄入的适应症。使用保持在室温下的蒸馏水进行皱纹测试。使用纳米导管汗液分析系统对在3分钟内患有AWP的儿童进行汗液氯化物分析。记录起皱的平均/中位时间,并在平滑后呈现为百分位曲线。
结果：1-15岁儿童的平均（SD）和中位数（四分位距[IQR]）水皱纹时间分别为4.88（1.066）和5（4-5.75）分钟。男孩AWP的平均（SD）和中位数（IQR）时间分别为4.78（1.076）和5（4-5）分钟，4.98（1.048）和5（4-6）分钟，分别为女孩。观察到皱纹所花费的时间随着年龄而增加。男性的AWP比女性早。AWP与人体测量法或汗液氯化物水平之间没有关联。
结论：我们估计了1-15岁儿童AWP的规范数据，可用于资源有限的典型临床特征儿童的CF筛查。
目的：生成1-15岁儿童AWP的规范数据，并描述与之相关的因素。
方法：1-15岁的儿童在获得父母和儿童的知情同意并根据年龄进行登记。关于年龄的信息，性别,人体测量学,记录了访问医院和药物摄入的适应症。使用保持在室温下的蒸馏水进行皱纹测试。使用纳米导管汗液分析系统对在3分钟内患有AWP的儿童进行汗液氯化物分析。记录起皱的平均/中位时间,并在平滑后呈现为百分位曲线。
结果：1-15岁儿童的平均（SD）和中位数（四分位距[IQR]）水皱纹时间分别为4.88（1.066）和5（4-5.75）分钟。男孩AWP的平均（SD）和中位数（IQR）时间分别为4.78（1.076）和5（4-5）分钟，4.98（1.048）和5（4-6）分钟，分别为女孩。观察到皱纹所花费的时间随着年龄而增加。男性的AWP比女性早。AWP与人体测量法或汗液氯化物水平之间没有关联。
结论：我们估计了1-15岁儿童AWP的规范数据，可用于资源有限的典型临床特征儿童的CF筛查。
