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Abstract：
OBJECTIVE: To explore the existing salivary, gingival crevicular fluid (GCF), blood, and serum biomarkers associated with grade C molar-incisor pattern (C/MIP) periodontitis in systemically healthy children and young adults.
METHODS: Cross-sectional, case-control, and cohort studies on stage III grade C periodontitis or former equivalent diagnosis with analysis of molecular biomarkers in saliva, GCF, blood, or serum were retrieved from six databases and screened based on the eligibility criteria. The risk of bias in included studies was evaluated. Meta-analysis was planned for biomarkers assessed using the same detection methods and sample type in at least two papers.
RESULTS: Out of 5621 studies identified at initial screening, 28 papers were included in the qualitative analysis of which 2 were eligible for meta-analysis for IgG in serum samples. Eighty-seven biomarkers were assessed with the majority being higher in cases than in controls. Only the meta-analysis of total serum IgG with low heterogeneity value revealed a significant increase in its levels in C/MIPs compared to controls (standardised mean difference: 1.08; 95% CI: 0.76, 1.40).
CONCLUSIONS: There is a paucity of data on biomarkers associated with molar-incisor pattern periodontitis. Although serum IgG levels are raised, other more specific biomarkers in saliva, GCF, and blood/serum may be promising but require further investigation.
METHODS: Cross-sectional, case-control, and cohort studies on stage III grade C periodontitis or former equivalent diagnosis with analysis of molecular biomarkers in saliva, GCF, blood, or serum were retrieved from six databases and screened based on the eligibility criteria. The risk of bias in included studies was evaluated. Meta-analysis was planned for biomarkers assessed using the same detection methods and sample type in at least two papers.
RESULTS: Out of 5621 studies identified at initial screening, 28 papers were included in the qualitative analysis of which 2 were eligible for meta-analysis for IgG in serum samples. Eighty-seven biomarkers were assessed with the majority being higher in cases than in controls. Only the meta-analysis of total serum IgG with low heterogeneity value revealed a significant increase in its levels in C/MIPs compared to controls (standardised mean difference: 1.08; 95% CI: 0.76, 1.40).
CONCLUSIONS: There is a paucity of data on biomarkers associated with molar-incisor pattern periodontitis. Although serum IgG levels are raised, other more specific biomarkers in saliva, GCF, and blood/serum may be promising but require further investigation.
摘要：
目的：探索现有的唾液，龈沟液（GCF），血,在系统健康的儿童和年轻人中，与C级磨牙切牙模式（C/MIP）牙周炎相关的血清生物标志物。
方法：横截面，病例控制，和关于III期C级牙周炎或先前等效诊断的队列研究，并分析唾液中的分子生物标志物，GCF,血,或从6个数据库中检索血清,并根据入选标准进行筛选.评估纳入研究的偏倚风险。计划对至少两篇论文中使用相同的检测方法和样品类型评估的生物标志物进行荟萃分析。
结果：在初步筛选时确定的5621项研究中，28篇论文被纳入定性分析，其中2篇有资格进行血清样品中IgG的荟萃分析。评估了87种生物标志物，其中大多数在病例中高于对照组。只有具有低异质性值的总血清IgG的荟萃分析显示，与对照组相比，其C/MIP水平显着增加（标准化平均差异：1.08；95％CI：0.76，1.40）。
结论：关于与磨牙切牙型牙周炎相关的生物标志物的数据很少。虽然血清IgG水平升高，唾液中其他更具体的生物标志物，GCF,和血液/血清可能是有希望的，但需要进一步调查。
方法：横截面，病例控制，和关于III期C级牙周炎或先前等效诊断的队列研究，并分析唾液中的分子生物标志物，GCF,血,或从6个数据库中检索血清,并根据入选标准进行筛选.评估纳入研究的偏倚风险。计划对至少两篇论文中使用相同的检测方法和样品类型评估的生物标志物进行荟萃分析。
结果：在初步筛选时确定的5621项研究中，28篇论文被纳入定性分析，其中2篇有资格进行血清样品中IgG的荟萃分析。评估了87种生物标志物，其中大多数在病例中高于对照组。只有具有低异质性值的总血清IgG的荟萃分析显示，与对照组相比，其C/MIP水平显着增加（标准化平均差异：1.08；95％CI：0.76，1.40）。
结论：关于与磨牙切牙型牙周炎相关的生物标志物的数据很少。虽然血清IgG水平升高，唾液中其他更具体的生物标志物，GCF,和血液/血清可能是有希望的，但需要进一步调查。
