Abstract：
To examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J mice. These results suggest that blindness impairs sleep quality.
摘要：
为了检查失明对睡眠/觉醒状态的影响，我们比较了有视力的CBA/N和失明的CBA/J小鼠在光照和黑暗期间由催眠药诱导的异氟烷麻醉后的运动活动和延迟恢复.在两只小鼠中，从黑暗到光明时期的转换周围的运动活动显着不同。在CBA/J小鼠中，溴替唑仑诱导的延迟恢复在两个时期都减弱。此外,在CBA/J小鼠中，suvorexant或苯海拉明引起的CBA/N小鼠延迟恢复的时期特异性被消除。这些结果表明，失明会损害睡眠质量。
