{Reference Type}: Journal Article
{Title}: Effects of Blindness on Sleep/Wakefulness States in Mice.
{Author}: Iba Y;En S;Yamada Y;Koami M;Yamamoto N;Sawada S;Yamawaki N;
{Journal}: Biol Pharm Bull
{Volume}: 46
{Issue}: 8
{Year}: 2023
{Factor}: 2.264
{DOI}: 10.1248/bpb.b23-00210
{Abstract}: To examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J mice. These results suggest that blindness impairs sleep quality.