Abstract：
Trace- and macro-chemical elements are crucial for cellular physiological functioning, and their alterations in biological fluids might be associated with an underlying pathological state. Hence, this study aimed to examine and summarize the published literature concerning the application of salivary ionomics for caries diagnosis. An extensive search of studies was conducted using PubMed, EMBASE, Web of Science, and Scopus, without any language and year restriction for answering the following PECO question: \"In subjects (i.e., children, adolescents, or adults) with good systematic health, are there any variations in the salivary concentrations of trace- or macro-elements between caries-free (CF) individuals and caries-active (CA) subjects?\" A modified version of the QUADOMICS tool was used to assess the quality of the included studies. The Review Manager Version 5.4.1. was used for data analyses. The analysis of salivary chemical elements that significantly differed between CF and CA subjects was also performed. Thirty-four studies were included, involving 2299 CA and 1669 CF subjects, having an age range from 3 to 64 years in over 16 countries. The meta-analysis revealed a statistically significant difference (p < 0.05) in the salivary levels of calcium, phosphorus, chloride, magnesium, potassium, sodium, and zinc between CA and CF subjects, suggesting higher levels of calcium, phosphorus, potassium, and sodium in CF subjects while higher levels of chloride, magnesium, and zinc in CA patients. Half of the included studies (17/34) were considered high quality, while the remaining half were considered medium quality. Only zinc and chloride ions were found to be higher significantly and consistent in CF and CA subjects, respectively. Conflicting outcomes were observed for all other salivary chemical elements including aluminum, bromine, calcium, copper, fluoride, iron, potassium, magnesium, manganese, sodium, ammonia, nitrite, nitrate, phosphorus, lead, selenium, and sulfate ions.
摘要：
微量和宏观化学元素对细胞生理功能至关重要，它们在生物体液中的改变可能与潜在的病理状态有关。因此，本研究旨在检查和总结已发表的有关唾液组学在龋齿诊断中的应用的文献。使用PubMed进行了广泛的研究搜索，EMBASE,WebofScience,还有Scopus,没有任何语言和年份限制来回答以下PECO问题：“在科目(即，孩子们,青少年,或成人)具有良好的系统健康状况，无龋齿（CF）个体和有龋齿活动（CA）受试者之间的唾液示踪或宏观元素浓度是否存在差异？\“QUADOMICS工具的改进版本用于评估纳入研究的质量。ReviewManager版本5.4.1。用于数据分析。还进行了CF和CA受试者之间显着不同的唾液化学元素的分析。纳入了34项研究，涉及2299名CA和1669名CF受试者，在16个国家/地区的年龄范围为3至64岁。荟萃分析显示，唾液钙水平差异有统计学意义（p<0.05），磷，氯化物,镁，钾，钠,CA和CF受试者之间的锌，表明钙含量较高，磷，钾，CF受试者中的钠，而氯化物水平较高，镁，CA患者的锌。纳入研究的一半（17/34）被认为是高质量的，而其余一半被认为是中等质量。只有在CF和CA受试者中发现锌和氯离子显著较高且一致。分别。所有其他唾液化学元素，包括铝，溴,钙，铜，氟化物,铁,钾，镁，锰，钠,氨,亚硝酸盐,硝酸盐,磷，铅,硒,和硫酸根离子。
