Abstract：
Core-shell nanostructures of silicon oxide@noble metal have drawn a lot of interest due to their distinctive characteristics and minimal toxicity with remarkable biocompatibility. Due to the unique property of localized surface plasmon resonance (LSPR), plasmonic nanoparticles are being used as surface-enhanced Raman scattering (SERS) based detection of pollutants and photothermal (PT) agents in cancer therapy. Herein, we demonstrate the synthesis of multifunctional silica core - Au nanostars shell (SiO2 @Au NSs) nanostructures using surfactant free aqueous phase method. The SERS performance of the as-synthesized anisotropic core-shell NSs was examined using Rhodamine B (RhB) dye as a Raman probe and resulted in strong enhancement factor of 1.37×106 . Furthermore, SiO2 @Au NSs were also employed for PT killing of breast cancer cells and they exhibited a concentration-dependent increase in the photothermal effect. The SiO2 @Au NSs show remarkable photothermal conversion efficiency of up to 72 % which is unprecedented. As an outcome, our synthesized NIR active SiO2 @Au NSs are of pivotal importance to have their dual applications in SERS enhancement and PT effect.
摘要：
氧化硅@贵金属的核-壳纳米结构由于其独特的特性和最小的毒性以及显着的生物相容性而引起了人们的极大兴趣。由于局域表面等离子体共振(LSPR)的独特性质,等离子体纳米粒子在癌症治疗中被用作基于表面增强拉曼散射（SERS）的污染物和光热（PT）试剂的检测。在这里，我们证明了使用无表面活性剂的水相方法合成多功能二氧化硅核-Au纳米星壳（SiO2@AuNSs）纳米结构。使用罗丹明B（RhB）染料作为拉曼探针检查了合成的各向异性核壳NSs的SERS性能，并产生了1.37×106的强增强因子。此外，SiO2@AuNS也用于PT杀伤乳腺癌细胞，它们表现出浓度依赖性的光热效应增加。SiO2@AuNS显示出高达72％的显着光热转换效率，这是前所未有的。作为一个结果,我们合成的近红外活性SiO2@AuNSs对于在SERS增强和PT效应中具有双重应用至关重要。
