PDF(Pubmed)
Abstract：
The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particularly regarding the relative contribution of the balancing selection in shaping MHC spatial variation and diversity compared to neutral forces.
In this study, we investigated the immunogenic variation of the striped hamster in four wild populations in Inner Mongolia which experience a heterogeneous parasitic burden. Our goal was to identify local adaptation by comparing the genetic structure at the MHC with that at seven microsatellite loci, taking into account neutral processes.
We observed significant variation in parasite pressure among sites, with parasite burden showing a correlation with temperature and precipitation. Molecular analysis revealed a similar co-structure between MHC and microsatellite loci. We observed lower genetic differentiation at MHC loci compared to microsatellite loci, and no correlation was found between the two.
Overall, these results suggest a complex interplay between neutral evolutionary forces and balancing selection in shaping the spatial patterns of MHC variation. Local adaptation was not detected on a small scale but may be applicable on a larger scale.
In this study, we investigated the immunogenic variation of the striped hamster in four wild populations in Inner Mongolia which experience a heterogeneous parasitic burden. Our goal was to identify local adaptation by comparing the genetic structure at the MHC with that at seven microsatellite loci, taking into account neutral processes.
We observed significant variation in parasite pressure among sites, with parasite burden showing a correlation with temperature and precipitation. Molecular analysis revealed a similar co-structure between MHC and microsatellite loci. We observed lower genetic differentiation at MHC loci compared to microsatellite loci, and no correlation was found between the two.
Overall, these results suggest a complex interplay between neutral evolutionary forces and balancing selection in shaping the spatial patterns of MHC variation. Local adaptation was not detected on a small scale but may be applicable on a larger scale.
摘要：
主要组织相容性复合体（MHC）由于其非凡的多态性而在对病原体的适应性免疫应答中起着关键作用。然而,条纹仓鼠MHC变异的空间格局仍不清楚，特别是关于与中性力相比，平衡选择在塑造MHC空间变异和多样性方面的相对贡献。
在这项研究中,我们调查了内蒙古四个野生种群中条纹仓鼠的免疫原性变化，这些种群经历了异质寄生负担。我们的目标是通过比较MHC与七个微卫星位点的遗传结构来确定局部适应，考虑到中立的过程。
我们观察到不同地点之间寄生虫压力的显著变化，寄生虫负荷与温度和降水有关。分子分析显示MHC和微卫星基因座之间具有相似的共结构。与微卫星基因座相比，我们观察到MHC基因座的遗传分化较低，两者之间没有相关性。
总的来说，这些结果表明,在形成MHC变异的空间模式时,中性进化力和平衡选择之间存在复杂的相互作用.未在小规模上检测到本地适应，但可能在更大规模上适用。
在这项研究中,我们调查了内蒙古四个野生种群中条纹仓鼠的免疫原性变化，这些种群经历了异质寄生负担。我们的目标是通过比较MHC与七个微卫星位点的遗传结构来确定局部适应，考虑到中立的过程。
我们观察到不同地点之间寄生虫压力的显著变化，寄生虫负荷与温度和降水有关。分子分析显示MHC和微卫星基因座之间具有相似的共结构。与微卫星基因座相比，我们观察到MHC基因座的遗传分化较低，两者之间没有相关性。
总的来说，这些结果表明,在形成MHC变异的空间模式时,中性进化力和平衡选择之间存在复杂的相互作用.未在小规模上检测到本地适应，但可能在更大规模上适用。
