Abstract：
BACKGROUND: Myxoid liposarcoma is a soft tissue sarcoma associated with multifocal metastases at diagnosis. These metastases are asymptomatic and occult on CT and FDG-PET and can alter the therapeutic management and prognosis. In this context, we evaluated the contribution of whole-body MRI to the initial workup of patients with myxoid liposarcoma.
METHODS: This retrospective study was conducted between January 2015 and December 2020 at the Oscar Lambret Center. We enrolled 22 patients who were diagnosed with myxoid liposarcoma and underwent whole-body MRI at diagnosis. The number of metastases at diagnosis, their location, and the visibility of these lesions on CT were evaluated. Associations between clinical features, presence of metastasis, and their impact on management were assessed.
RESULTS: Sixteen patients (72.7%) had non-metastatic disease at the initial diagnosis, and 15 of these patients were managed using local treatment. Six patients (27.3%) had metastases at multiple locations and received chemotherapy. The main locations were the bones (n=5) and lungs (n=3). In five patients with metastases, whole-body MRI demonstrated additional lesions that were not visible on CT (bone and soft tissue lesions). Only the presence of a round cell contingent (P=0.009) was found as a criterion associated with the presence of metastases.
CONCLUSIONS: The patients\' young age, absence of reliable prognostic factors at diagnosis, asymptomatic nature of the lesions, and the benefits of early and targeted therapeutic management encourage the use of whole-body MRI as part of the initial work-up as it seems to provide a better initial staging compared with conventional imaging.
METHODS: This retrospective study was conducted between January 2015 and December 2020 at the Oscar Lambret Center. We enrolled 22 patients who were diagnosed with myxoid liposarcoma and underwent whole-body MRI at diagnosis. The number of metastases at diagnosis, their location, and the visibility of these lesions on CT were evaluated. Associations between clinical features, presence of metastasis, and their impact on management were assessed.
RESULTS: Sixteen patients (72.7%) had non-metastatic disease at the initial diagnosis, and 15 of these patients were managed using local treatment. Six patients (27.3%) had metastases at multiple locations and received chemotherapy. The main locations were the bones (n=5) and lungs (n=3). In five patients with metastases, whole-body MRI demonstrated additional lesions that were not visible on CT (bone and soft tissue lesions). Only the presence of a round cell contingent (P=0.009) was found as a criterion associated with the presence of metastases.
CONCLUSIONS: The patients\' young age, absence of reliable prognostic factors at diagnosis, asymptomatic nature of the lesions, and the benefits of early and targeted therapeutic management encourage the use of whole-body MRI as part of the initial work-up as it seems to provide a better initial staging compared with conventional imaging.
摘要：
背景：粘液样脂肪肉瘤是一种在诊断时与多灶性转移相关的软组织肉瘤。这些转移在CT和FDG-PET上是无症状且隐匿的，并且可以改变治疗管理和预后。在这种情况下，我们评估了全身MRI对黏液样脂肪肉瘤患者初始检查的贡献.
方法：这项回顾性研究于2015年1月至2020年12月在OscarLambret中心进行。我们招募了22例诊断为黏液样脂肪肉瘤并在诊断时接受全身MRI检查的患者。诊断时转移的数量，他们的位置,并评估这些病变在CT上的可见性。临床特征之间的关联，转移的存在，并评估了它们对管理的影响。
结果：16例患者（72.7%）在初次诊断时患有非转移性疾病，其中15例患者采用局部治疗.6例患者（27.3%）在多个位置发生转移并接受化疗。主要位置是骨骼（n=5）和肺（n=3）。在五名转移患者中，全身MRI显示CT上看不到的额外病变(骨和软组织病变).仅发现圆形细胞特遣队的存在（P=0.009）作为与转移的存在相关的标准。
结论：患者年龄小，诊断时缺乏可靠的预后因素，病变的无症状性质，早期和有针对性的治疗管理的益处鼓励使用全身MRI作为初始检查的一部分,因为与常规成像相比,它似乎提供了更好的初始分期.
方法：这项回顾性研究于2015年1月至2020年12月在OscarLambret中心进行。我们招募了22例诊断为黏液样脂肪肉瘤并在诊断时接受全身MRI检查的患者。诊断时转移的数量，他们的位置,并评估这些病变在CT上的可见性。临床特征之间的关联，转移的存在，并评估了它们对管理的影响。
结果：16例患者（72.7%）在初次诊断时患有非转移性疾病，其中15例患者采用局部治疗.6例患者（27.3%）在多个位置发生转移并接受化疗。主要位置是骨骼（n=5）和肺（n=3）。在五名转移患者中，全身MRI显示CT上看不到的额外病变(骨和软组织病变).仅发现圆形细胞特遣队的存在（P=0.009）作为与转移的存在相关的标准。
结论：患者年龄小，诊断时缺乏可靠的预后因素，病变的无症状性质，早期和有针对性的治疗管理的益处鼓励使用全身MRI作为初始检查的一部分,因为与常规成像相比,它似乎提供了更好的初始分期.
