背景:黏液性脂肪肉瘤黏液样脂肪肉瘤是一种来源于血管周围未分化基质细胞的恶性黏液样软组织肿瘤,下体腔和肌肉间隙,由前脂肪细胞分化为成熟细胞的不同阶段的细胞组成。在极少数情况下,它可能会从脂肪瘤恶性肿瘤改变。主要表现为无痛肿块,相对缓慢的增长,课程可以持续几十年,脂肪肉瘤在人群中的患病率为14%至18%,主要是成年人,男性患病率高于女性,但不重要。主要的好头发部分是大腿,有粘液性,高分化型,去分化类型,多态类型。临床诊断困难,早期没有明显的症状,所以诊断要结合B超,MRI,CT,以及其他辅助考试。金标准是病理检查。2023年12月,我们部门收治了一名腹部黏液性肿块患者。报告如下。
方法:脂肪肉瘤会转移吗?手术后需要化疗吗?将来会复发吗?手术后的生存期是多少?
方法:粘液性脂肪肉瘤。
方法:手术切除肉瘤。
结果:结节样本为33*28*13厘米,有完整的胶囊,灰色和黄色部分,质地细腻,软,灰色,红色,灰色,和黄色的粘液结节在某些地区,结节最大直径为21cm。免疫组化为:CD34(+),CDK4(+),CK(-),Desmin(弱+),Ki67(指数5%),MDM2(-),p16(弱+),S-100P(+),波形蛋白(+),BCL-2(+)。他还被送到北京协和医院病理科与陆朝晖教授会诊,其咨询意见与黏液脂肪肉瘤一致。
结论:腹膜后脂肪肉瘤是一种常见的腹膜后肿瘤,但在临床实践中相对罕见;总体发病率较低,主要表现为腹痛和腹胀,腹胀,病程长;对放疗和化疗不敏感,并应密切随访CT检查以了解复发和转移。
BACKGROUND: Mucinous liposarcoma myxoid liposarcoma is a malignant mucoid soft tissue tumor derived from undifferentiated stromal cells in perivascular, subbody cavity and intermuscular space, and composed of cells at different stages of differentiation from preadipocytes to mature cells. In rare cases, it may change from lipoma malignancy. The main manifestations is painless mass, relatively slow growth, the course can last decades, the prevalence of liposarcoma in the population is 14% to 18%, mainly in adults, male prevalence is higher than women, but not significant. The main good hair part is the thigh, have mucinous sex, high differentiation type, dedifferentiation type, polymorphic type. Clinical diagnosis is difficult, and there are no obvious symptoms in the early stage, so the diagnosis should be combined with B ultrasound, MRI, CT, and other auxiliary examinations. The gold standard is pathological examination. In December 2023, our department admitted a patient with a mucinous abdominal mass. The report is as follows.
METHODS: Does liposarcoma metastasize? Is any chemotherapy required after surgery? Will it ever relapse in the future? What is the survival period after surgery?
METHODS: Mucinous liposarcoma.
METHODS: Surgical resection of the sarcoma.
RESULTS: The nodule sample was 33 * 28 * 13 cm, with complete capsule, gray and yellow sections, fine texture, soft, gray, red, grayish, and yellow mucoid nodules in some areas, and the maximum diameter of the nodules was 21cm. Immunohistochemistry was: CD34 (+), CDK 4 (+), CK (-), Desmin (weak +), Ki67 (index 5%), MDM 2 (-), p16 (weak +), S-100P (+), Vimentin (+), BCL-2 (+). He was also sent to the Department of Pathology of Peking Union Medical College Hospital for consultation with Professor Lu Zhaohui, whose consultation opinion was in line with myxoliposarcoma.
CONCLUSIONS: Retroperitoneal liposarcoma is a common retroperitoneal tumor, but it is relatively rare in clinical practice; the overall morbidity is low, mainly manifested as abdominal pain and abdominal distension, abdominal distension, and a long course of disease; it is not sensitive to radiotherapy and chemotherapy, and should be closely follow up by CT examination to understand the recurrence and metastasis.