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Abstract：
Li Li, Lin Lin, Bo Wen, Peng-cheng Zhao, Da-sheng Liu, Guo-ming Pang, Zi-rong Wang, Yong Tan, and Cheng Lu. Promising natural medicines for the treatment of high-altitude illness. High Alt Med Biol. 24:175-185, 2023.-High-altitude illness (HAI) is a dangerous disease characterized by oxidative stress, inflammatory damage and hemodynamic changes in the body that can lead to severe damage to the lungs, heart, and brain. Natural medicines are widely known for their multiple active ingredients and pharmacological effects, which may be important in the treatment of HAI. In this review, we outline the specific types of HAI and the underlying pathological mechanisms and summarize the currently documented natural medicines applied in the treatment of acute mountain sickness and high-altitude cerebral edema, high-altitude pulmonary edema, chronic mountain sickness, and high-altitude pulmonary hypertension. Their sources, types, and medicinal sites are summarized, and their active ingredients, pharmacological effects, related mechanisms, and potential toxicity are discussed. In conclusion, natural medicines, as an acceptable complementary and alternative strategy with fewer side effects and more long-term application, can provide a reference for developing more natural antialtitude sickness medicines in the future and have good application prospects in HAI treatment.
摘要：
李莉,林林,博文,赵鹏成,刘大胜,庞国明,王子荣,YongTan,和程璐。有希望的天然药物用于治疗高原病。高AltMedBiol。24:175-185，2023年。-高海拔疾病（HAI）是一种以氧化应激为特征的危险疾病，体内的炎症损伤和血液动力学变化可能导致肺部严重损伤，心,和大脑。天然药物以其多种活性成分和药理作用而广为人知，这对HAI的治疗可能很重要。在这次审查中,我们概述了HAI的具体类型和潜在的病理机制，并总结了目前文献记载的用于治疗急性高山病和高原脑水肿的天然药物，高原肺水肿,慢性高山病,和高海拔肺动脉高压.他们的来源,类型,和药用场所进行了总结，和它们的活性成分，药理作用，相关机制,并讨论了潜在的毒性。总之,天然药物,作为一种可接受的补充和替代策略，副作用更少，应用更长期，可为今后开发更多天然抗高原病药物提供参考,在HAI治疗中具有良好的应用前景。
