Abstract：
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia seen primarily in women of African descent but rarely reported in men. The etiology of CCCA is unknown, but genetic variants, type 2 diabetes mellitus, and bacterial infections may play a role.
We aimed to characterize the demographics, medical histories, and clinical findings of male patients with CCCA with the hypothesis that features may differ from women.
This was a case series of adult male patients with biopsy-confirmed CCCA seen at an academic dermatology department between 2012 and 2022.
In total, 17 males had a scalp biopsy and clinical findings consistent with CCCA. The average age was 43 years, and 88.2% of cases identified as Black race. Scalp pruritus was the most common symptom, and few patients endorsed high-risk hair care practices. None of the cases had diagnosis of type 2 diabetes mellitus, but 17.6% had history of latent tuberculosis, and 47.1% had a positive family history of alopecia. We observed 8 patients with atypical CCCA, and 29.4% had an overlapping scalp diagnosis.
This study is limited by the single center, retrospective design and small sample size.
It is important to consider CCCA in the differential diagnosis of alopecia in adult Black males.
We aimed to characterize the demographics, medical histories, and clinical findings of male patients with CCCA with the hypothesis that features may differ from women.
This was a case series of adult male patients with biopsy-confirmed CCCA seen at an academic dermatology department between 2012 and 2022.
In total, 17 males had a scalp biopsy and clinical findings consistent with CCCA. The average age was 43 years, and 88.2% of cases identified as Black race. Scalp pruritus was the most common symptom, and few patients endorsed high-risk hair care practices. None of the cases had diagnosis of type 2 diabetes mellitus, but 17.6% had history of latent tuberculosis, and 47.1% had a positive family history of alopecia. We observed 8 patients with atypical CCCA, and 29.4% had an overlapping scalp diagnosis.
This study is limited by the single center, retrospective design and small sample size.
It is important to consider CCCA in the differential diagnosis of alopecia in adult Black males.
摘要：
背景：中央离心瘢痕性脱发（CCCA）是一种瘢痕性脱发，主要见于非洲裔女性，但很少见于男性。CCCA的病因不明,但是遗传变异，II型糖尿病（T2DM），1-3目标：我们旨在表征人口统计学，病史,以及男性CCCA患者的临床表现，假设其特征可能与女性不同。
方法：这是2012年至2022年在皮肤科就诊的经活检证实的CCCA成年男性患者的病例系列。
结果：总计，17名男性进行了头皮活检，临床表现与CCCA一致。平均年龄43岁,88.2%的病例被确定为黑人。头皮瘙痒是最常见的症状，很少有患者支持高风险的护发实践。所有病例均未诊断为T2DM，但17.6%有潜伏性结核病史,47.1%有脱发家族史。我们观察到8例非典型CCCA患者，29.4%的患者有重叠的头皮诊断。
结论：这项研究受到单中心的限制，回顾性设计和小样本量。
结论：在成年黑人男性脱发的鉴别诊断中考虑CCCA非常重要。
方法：这是2012年至2022年在皮肤科就诊的经活检证实的CCCA成年男性患者的病例系列。
结果：总计，17名男性进行了头皮活检，临床表现与CCCA一致。平均年龄43岁,88.2%的病例被确定为黑人。头皮瘙痒是最常见的症状，很少有患者支持高风险的护发实践。所有病例均未诊断为T2DM，但17.6%有潜伏性结核病史,47.1%有脱发家族史。我们观察到8例非典型CCCA患者，29.4%的患者有重叠的头皮诊断。
结论：这项研究受到单中心的限制，回顾性设计和小样本量。
结论：在成年黑人男性脱发的鉴别诊断中考虑CCCA非常重要。
