模拟引起神经胶质瘤的表观遗传病变。
关键词: CDKN2A DNA methylation IDH mutation PDGFRA cell of origin chromatin genome topology glioma nuclear architecture oligodendrocyte progenitor cells
Mesh : Animals Humans Mice Brain Neoplasms / genetics pathology DNA Methylation Epigenesis, Genetic Glioma / genetics pathology Isocitrate Dehydrogenase / genetics Mutation Oncogenes Receptor, Platelet-Derived Growth Factor alpha / genetics
来 源:
DOI:10.1016/j.cell.2023.06.022
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