Abstract：
BACKGROUND: There is an ongoing debate if weekend admissions of critically ill patients are associated with higher mortality rates. The current review aimed to specifically assess this effect in sepsis and septic shock patients by comparing mortality rates with weekend versus weekday admissions.
METHODS: PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched up to 20th February 2023 with an additional search of Google Scholar for gray literature.
RESULTS: Nine studies were eligible. Meta-analysis of all nine studies with data from 1,134,417 patients demonstrated that sepsis or septic shock patients admitted on weekends don\'t have higher mortality as compared to those admitted on weekdays (OR: 1.04; 95% CI: 1.00, 1.09; p = 0.05; I2 = 93%). On subgroup analysis based on sample size (>2000 or <2000 patients) and timing of mortality, we noted no difference in the significance of the results. However, there was a small significant increased risk of mortality with weekend admission noted in studies on the Asian population and including septic shock patients.
CONCLUSIONS: Weekend admission does not have an adverse impact on mortality rates of sepsis and septic shock patients. Results must be interpreted with caution owing to high interstudy heterogeneity and variation in confounders adjusted by individual studies.
METHODS: PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched up to 20th February 2023 with an additional search of Google Scholar for gray literature.
RESULTS: Nine studies were eligible. Meta-analysis of all nine studies with data from 1,134,417 patients demonstrated that sepsis or septic shock patients admitted on weekends don\'t have higher mortality as compared to those admitted on weekdays (OR: 1.04; 95% CI: 1.00, 1.09; p = 0.05; I2 = 93%). On subgroup analysis based on sample size (>2000 or <2000 patients) and timing of mortality, we noted no difference in the significance of the results. However, there was a small significant increased risk of mortality with weekend admission noted in studies on the Asian population and including septic shock patients.
CONCLUSIONS: Weekend admission does not have an adverse impact on mortality rates of sepsis and septic shock patients. Results must be interpreted with caution owing to high interstudy heterogeneity and variation in confounders adjusted by individual studies.
摘要：
背景：危重病人周末入院是否与较高的死亡率相关，目前仍存在争议。本综述旨在通过比较周末和平日入院的死亡率来具体评估脓毒症和脓毒性休克患者的这种影响。
方法：PubMed，中部,Scopus,WebofScience,和Embase在2023年2月20日之前进行了搜索，并额外搜索了GoogleScholar的灰色文献。
结果：有9项研究合格。对来自1,134,417名患者的所有9项研究的荟萃分析表明，与平日入院的患者相比，周末入院的败血症或败血症性休克患者的死亡率并不高（OR：1.04；95％CI：1.00，1.09；p=0.05；I2=93％）。基于样本量（>2000或<2000名患者）和死亡时间的亚组分析，我们注意到结果的显著性没有差异.然而,在对亚洲人群,包括感染性休克患者的研究中,周末入院后死亡风险有小幅显著增加.
结论：周末入院对脓毒症和脓毒性休克患者的死亡率没有不利影响。必须谨慎解释结果，因为研究间的高度异质性和根据个别研究调整的混杂因素的差异。
方法：PubMed，中部,Scopus,WebofScience,和Embase在2023年2月20日之前进行了搜索，并额外搜索了GoogleScholar的灰色文献。
结果：有9项研究合格。对来自1,134,417名患者的所有9项研究的荟萃分析表明，与平日入院的患者相比，周末入院的败血症或败血症性休克患者的死亡率并不高（OR：1.04；95％CI：1.00，1.09；p=0.05；I2=93％）。基于样本量（>2000或<2000名患者）和死亡时间的亚组分析，我们注意到结果的显著性没有差异.然而,在对亚洲人群,包括感染性休克患者的研究中,周末入院后死亡风险有小幅显著增加.
结论：周末入院对脓毒症和脓毒性休克患者的死亡率没有不利影响。必须谨慎解释结果，因为研究间的高度异质性和根据个别研究调整的混杂因素的差异。
