PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the role of family history of preterm delivery (PTD) in the individual risk of spontaneous preterm delivery.
METHODS: A retrospective case-control study was conducted on 354 patients who delivered between 2018 and 2020. 177 women who delivered preterm were matched with 177 controls who had full-term delivery. A questionnaire was administered to investigate the family history of PTD of both the patient and her partner. Cases and controls were matched for the anamnestic risk factors for PTD.
RESULTS: Seventeen of 173 women (9.8%) in the PTD group reported being born preterm, compared to five of 169 women (2.9%) in the control group (p = 0.01), with an odds ratio (OR) of 3.57 (95% confidence interval, CI 1.29-9.92). Women who delivered preterm also reported more frequently having a sibling who was born preterm (12.4% vs. 4.2%, p = 0.01), with an OR of 3.18 (95% CI 1.31-7.7). No association was found between the partner\'s family history of premature delivery and the patient\'s risk of preterm delivery in the present pregnancy.
CONCLUSIONS: Pregnant patients who were born prematurely or who have siblings born preterm have an increased risk of preterm delivery in their own pregnancies. Assessment of female personal and family history of PTD should be used to identify women at risk of having a PTD in the present pregnancy.
METHODS: A retrospective case-control study was conducted on 354 patients who delivered between 2018 and 2020. 177 women who delivered preterm were matched with 177 controls who had full-term delivery. A questionnaire was administered to investigate the family history of PTD of both the patient and her partner. Cases and controls were matched for the anamnestic risk factors for PTD.
RESULTS: Seventeen of 173 women (9.8%) in the PTD group reported being born preterm, compared to five of 169 women (2.9%) in the control group (p = 0.01), with an odds ratio (OR) of 3.57 (95% confidence interval, CI 1.29-9.92). Women who delivered preterm also reported more frequently having a sibling who was born preterm (12.4% vs. 4.2%, p = 0.01), with an OR of 3.18 (95% CI 1.31-7.7). No association was found between the partner\'s family history of premature delivery and the patient\'s risk of preterm delivery in the present pregnancy.
CONCLUSIONS: Pregnant patients who were born prematurely or who have siblings born preterm have an increased risk of preterm delivery in their own pregnancies. Assessment of female personal and family history of PTD should be used to identify women at risk of having a PTD in the present pregnancy.
摘要：
目的：探讨早产家族史在自发性早产个体风险中的作用。
方法：对2018年至2020年期间分娩的354例患者进行了回顾性病例对照研究。177名早产的妇女与177名足月分娩的对照组相匹配。进行问卷调查以调查患者及其伴侣的PTD家族史。病例和对照对于PTD的记忆障碍危险因素进行匹配。
结果：PTD组中173名女性中有17名（9.8％）报告早产，与对照组169名女性中的5名(2.9%)相比(p=0.01)，比值比(OR)为3.57(95%置信区间，CI1.29-9.92）。早产的女性也报告说有兄弟姐妹早产的频率更高(12.4%vs.4.2%，p=0.01),OR为3.18（95%CI1.31-7.7）。未发现伴侣的早产家族史与患者目前妊娠早产风险之间存在关联。
结论：早产或兄弟姐妹早产的孕妇在自己怀孕期间早产的风险增加。对女性个人和家族PTD病史的评估应用于确定在当前怀孕中有PTD风险的女性。
方法：对2018年至2020年期间分娩的354例患者进行了回顾性病例对照研究。177名早产的妇女与177名足月分娩的对照组相匹配。进行问卷调查以调查患者及其伴侣的PTD家族史。病例和对照对于PTD的记忆障碍危险因素进行匹配。
结果：PTD组中173名女性中有17名（9.8％）报告早产，与对照组169名女性中的5名(2.9%)相比(p=0.01)，比值比(OR)为3.57(95%置信区间，CI1.29-9.92）。早产的女性也报告说有兄弟姐妹早产的频率更高(12.4%vs.4.2%，p=0.01),OR为3.18（95%CI1.31-7.7）。未发现伴侣的早产家族史与患者目前妊娠早产风险之间存在关联。
结论：早产或兄弟姐妹早产的孕妇在自己怀孕期间早产的风险增加。对女性个人和家族PTD病史的评估应用于确定在当前怀孕中有PTD风险的女性。
