背景:在亚洲,阿尔茨海默病(AD)患者的数量急剧增加。
目的:更新8个亚洲国家的AD患者的人口统计学特征及其信息,并与12年前进行比较。
方法:统一数据集(UDS)的A1-A3组件,3.0版,在台湾管理,北京,香港,韩国,Japan,菲律宾,泰国,和印度尼西亚。在同一地区,使用2010-2014年UDS1.0版与首次注册的AD患者进行了数据比较。
结果:从2022年到2024年共招募了1885名AD患者及其线人,并与十年前招募的2042名患者进行了比较。每个国家都有自己独特的特征,在两个时代之间发生了变化。患者和举报人的平均年龄为79.8±8.2岁和56.5±12.1岁,分别。与第一次注册相比,患者年龄较大(79.8vs79.0,p=0.002),整体功能较差(平均CDR-SB评分6.1vs5.8,p<0.001);更多的信息是儿童(56%vs.48%,p<0.001),如果不住在一起,他们的面对面访问频率显着增加。总共11%,4.5%,11%,0.4%的患者有母亲的认知障碍史,父亲们,兄弟姐妹,和孩子们,分别;所有百分比,除了孩子,在过去十年中大幅增加。
结论:本研究报告了亚洲国家AD患者及其受检者的异质性特征,以及过去十年的明显变化。发展中国家和发达国家在痴呆症评估和护理方面的差异值得进一步调查。
BACKGROUND: The number of patients with Alzheimer\'s disease (AD) has increased dramatically in Asia.
OBJECTIVE: To update the demographic characteristics of patients with AD and their informants in eight Asian countries and compare them from 12 years prior.
METHODS: The A1-A3 components of the Uniform Dataset (UDS), version 3.0, were administered in Taiwan, Beijing, Hong Kong, Korea, Japan, Philippines, Thailand, and Indonesia. Data were compared with patients with AD in the first registration using the UDS version 1.0 from 2010-2014 in the same regions.
RESULTS: A total of 1885 patients with AD and their informants were recruited from 2022 to 2024 and were compared with 2042 patients recruited a decade prior. Each country had its own unique characteristics that changed between both eras. The mean age of the patients and informants was 79.8±8.2 years and 56.5±12.1 years, respectively. Compared with the first registration, the patients were older (79.8 vs 79.0, p=0.002) and had worse global function (mean CDR-SB scores 6.1 vs 5.8, p<0.001); more informants were children (56 % vs. 48 %, p<0.001), and their frequency of in-person visits increased significantly if not living together. A total of 11 %, 4.5 %, 11 %, and 0.4 % of the patients had a reported history of cognitive impairment in their mothers, fathers, siblings, and children, respectively; all percentages, except children, increased significantly over the past decade.
CONCLUSIONS: The present study reports the heterogeneous characteristics of patients with AD and their informants in Asian countries, and the distinct changes in the past decade. The differences in dementia evaluation and care between developing and developed countries warrant further investigation.