PDF(Pubmed)
Abstract：
UNASSIGNED: There is as yet a paucity of data on intramedullary spinal cord tumours (IMSCTs) in sub-Saharan Africa. This study aims to define the clinical profile and outcome of management of IMSCTs in a Nigerian tertiary hospital.
UNASSIGNED: This is a retrospective study of all the patients who had surgery for IMSCTs in our hospital over a 14 year period.
UNASSIGNED: There were 20 patients, 9 males, 11 females, in this study. The median age was 33 years (range = 7-78 years). The median duration of symptoms was 12 months (range = 1-120 months). Motor deficit was present in all but one (95%) of our patients. Only 25% of the patients presented in good functional status (McCormick grades I and II). The tumours were confined to the thoracic region in 10 patients (50%), while tumours in the thoracic region extending to the adjoining cervical and lumbar regions were seen in 6 patients (30%). Gross total tumour resection was achieved in 60% of the patients and subtotal resection in the remaining 40%. Astrocytoma and ependymoma were the most common tumours, each occurring in 35% of the cases. Six patients (30.0%) improved, 12 patients (60.0%) remained neurologically the same, while 2 patients (10.0%) deteriorated at the time of last follow up. The mortality rate was 15%. The preoperative functional status was a significant predictor of postoperative outcome (p = 0.03).
UNASSIGNED: Astrocytoma and ependymoma were the most common histological tumour types among our patients. Late presentation and poor pre-operative functional status were prominent features of our patients\' cohort.
UNASSIGNED: This is a retrospective study of all the patients who had surgery for IMSCTs in our hospital over a 14 year period.
UNASSIGNED: There were 20 patients, 9 males, 11 females, in this study. The median age was 33 years (range = 7-78 years). The median duration of symptoms was 12 months (range = 1-120 months). Motor deficit was present in all but one (95%) of our patients. Only 25% of the patients presented in good functional status (McCormick grades I and II). The tumours were confined to the thoracic region in 10 patients (50%), while tumours in the thoracic region extending to the adjoining cervical and lumbar regions were seen in 6 patients (30%). Gross total tumour resection was achieved in 60% of the patients and subtotal resection in the remaining 40%. Astrocytoma and ependymoma were the most common tumours, each occurring in 35% of the cases. Six patients (30.0%) improved, 12 patients (60.0%) remained neurologically the same, while 2 patients (10.0%) deteriorated at the time of last follow up. The mortality rate was 15%. The preoperative functional status was a significant predictor of postoperative outcome (p = 0.03).
UNASSIGNED: Astrocytoma and ependymoma were the most common histological tumour types among our patients. Late presentation and poor pre-operative functional status were prominent features of our patients\' cohort.
摘要：
■在撒哈拉以南非洲，关于髓内脊髓肿瘤（IMSCT）的数据还很少。这项研究旨在定义尼日利亚三级医院IMSCT的临床概况和结果。
■这是一项回顾性研究，对在我们医院进行了14年的IMSCT手术的所有患者进行了回顾性研究。
■有20名患者，9名男性，11名女性,在这项研究中。中位年龄为33岁（范围=7-78岁）。症状的中位持续时间为12个月（范围=1-120个月）。除一名（95％）患者外，所有患者均存在运动缺陷。只有25％的患者表现出良好的功能状态（麦考密克I级和II级）。10例患者（50%）的肿瘤局限于胸部，而在6例患者（30％）中，胸部肿瘤延伸到相邻的颈椎和腰椎区域。60％的患者实现了总肿瘤切除，其余40％实现了次全切除。星形细胞瘤和室管膜瘤是最常见的肿瘤，每个都发生在35%的病例中。6例患者(30.0%)好转,12例（60.0%）患者的神经系统保持不变，而2例患者（10.0％）在最后一次随访时恶化。死亡率为15%。术前功能状态是术后预后的重要预测指标（p=0.03）。
■星形细胞瘤和室管膜瘤是我们患者中最常见的组织学肿瘤类型。延迟就诊和不良的术前功能状态是我们患者队列的突出特征。
■这是一项回顾性研究，对在我们医院进行了14年的IMSCT手术的所有患者进行了回顾性研究。
■有20名患者，9名男性，11名女性,在这项研究中。中位年龄为33岁（范围=7-78岁）。症状的中位持续时间为12个月（范围=1-120个月）。除一名（95％）患者外，所有患者均存在运动缺陷。只有25％的患者表现出良好的功能状态（麦考密克I级和II级）。10例患者（50%）的肿瘤局限于胸部，而在6例患者（30％）中，胸部肿瘤延伸到相邻的颈椎和腰椎区域。60％的患者实现了总肿瘤切除，其余40％实现了次全切除。星形细胞瘤和室管膜瘤是最常见的肿瘤，每个都发生在35%的病例中。6例患者(30.0%)好转,12例（60.0%）患者的神经系统保持不变，而2例患者（10.0％）在最后一次随访时恶化。死亡率为15%。术前功能状态是术后预后的重要预测指标（p=0.03）。
■星形细胞瘤和室管膜瘤是我们患者中最常见的组织学肿瘤类型。延迟就诊和不良的术前功能状态是我们患者队列的突出特征。
