Intramedullary

髓内
  • 文章类型: Journal Article
    目的:小儿脊髓髓内低级别胶质瘤(pLGGs)是小儿中枢神经系统(CNS)肿瘤中罕见的诊断。患者的经典表现包括一定程度的神经功能缺损,尽管很多时候症状模糊,导致诊断延迟。
    方法:诊断的第一步包括脊柱成像中的特殊参数,尤其是磁共振成像(MRI),手术切除仍然是诊断和治疗的基石。然而,近年来,在中枢神经系统肿瘤的分子和遗传学认识方面取得了进展,可以更好地调整治疗和随访方案.根据术后情况,辅助治疗可以为某些类型的肿瘤提供额外的治疗优势。
    结论:最终,在大多数小儿脊髓LGG病例中,如果接受适当治疗,患者的预后非常有希望,并且持续进展。该手稿总结了有关髓内pLGG的临床和治疗特征的最新证据。
    OBJECTIVE: Pediatric intramedullary spinal cord low-grade gliomas (pLGGs) are rare diagnoses among central nervous system (CNS) tumors in the pediatric population. The classic presentation of the patients includes some degree of neurologic deficit, although many times the symptoms are vague which leads to delayed diagnosis.
    METHODS: The first step in the diagnosis includes special parameters in spinal imaging, particularly magnetic resonance imaging (MRI), and surgical resection remains the cornerstone for both diagnosis and treatment. Yet, recent years advancement in molecular and genetic understanding of CNS tumors allows for better adjustment of the treatment and follow-up regimens. Based on postoperative status, adjuvant therapy may provide additional therapeutic advantage for some types of tumors.
    CONCLUSIONS: Ultimately, patients have a very promising prognosis when treated appropriately in most of the cases of pediatric spinal cord LGG with continued advances arising. This manuscript summarizes the most contemporary evidence regarding clinical and treatment features of intramedullary pLGGs.
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  • 文章类型: Case Reports
    髓内非恶性脊髓脂肪瘤在原发性脊髓肿瘤中极为罕见。这些患者表现出非特异性感觉症状,随后运动症状恶化。由于神经保存的安全界限很薄,精心定位肿瘤的范围和选择切除方式至关重要。
    作者报告了一例35岁男性罕见病例,表现为进行性行走困难6个月,伴有双侧上肢和下肢麻木和刺痛感。他被诊断患有非恶性髓内颈胸脂肪瘤,并接受了肿瘤的次全切除术。
    非恶性脊髓髓内脂肪瘤罕见,可表现为非特异性神经症状。因此,它们应该被认为是脊髓髓内肿瘤的差异。手术似乎是治疗的主要手段。
    UNASSIGNED: Intramedullary nondysraphic spinal lipomas are extremely rare among primary spinal cord tumors. These patients present with nonspecific sensory symptoms followed by deterioration of motor symptoms. As the safety margins for neurological preservation are thin, meticulously locating the extent of the tumor and choosing the resection modalities is essential.
    UNASSIGNED: The authors report a rare case of a 35-year-old male who presented with progressive difficulty in walking for 6 months associated with numbness and tingling sensation in the bilateral upper and lower limbs. He was diagnosed with nondysraphic intramedullary cervicothoracic lipoma and underwent subtotal resection of the tumor.
    UNASSIGNED: Nondysraphic intramedullary spinal cord lipomas are rare and may present as nonspecific neurological symptoms. Hence, they should be considered differentials of intramedullary spinal cord tumors. Surgery appears to be the mainstay of treatment.
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  • 文章类型: Journal Article
    本报告强调仔细考虑中指骨骨折髓内螺钉固定的手术技术。突出的陷阱,特别是在K线放置时,这表明顺行经关节入路优越,敦促进一步研究以改善患者预后。
    This report emphasizes careful consideration of surgical technique for intramedullary screw fixation in middle phalanx fractures. Highlighting pitfalls, particularly with K-wire placement, it suggests the antegrade trans-articular approach as superior, urging further research for improved patient outcomes.
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  • 文章类型: Journal Article
    背景:髓内螺钉(IMS)已成为掌骨折固定的可行选择。为了进一步评估它们的效用,本研究评估了IMS固定治疗掌关节外骨折的临床和患者报告的短期和中期结局.方法:在2020年1月至2023年7月的42个月期间,对32例患者(共37例骨折)进行了回顾性队列研究。结果:恢复工作的平均时间为39.8天;恢复全部功能的平均时间为88.4天;总主动运动为250.7°(范围:204.9-270.9);手臂快速残疾,肩和手评分为2.3(范围:0-22.7);平均视觉模拟疼痛评分为10分之0.9(范围:0-6),观察到单个并发症。结论:在掌骨骨折固定术中使用IMS是可行的手术选择。IMS固定为恢复功能提供了令人满意的持续时间,良好的术后运动范围,疼痛评分适中,并发症发生率低。证据级别:IV级(治疗)。
    Background: Intramedullary screws (IMS) have become a viable option for metacarpal fracture fixation. To further appraise their utility, this study assessed clinical and patient-reported short- and medium-term outcomes of IMS fixation for extra-articular metacarpal fractures. Methods: A retrospective cohort study was performed in a series of 32 patients (with a total of 37 fractures) who underwent metacarpal fracture fixation over a 42-month period between January 2020 and July 2023. Results: Mean time for return to work was 39.8 days; mean time for return to full function was 88.4 days; total active motion was 250.7° (range: 204.9-270.9); Quick Disabilities of the Arm, Shoulder and Hand score was 2.3 (range: 0-22.7); mean visual analogue pain score was 0.9 out of 10 (range: 0-6) and a single complication was observed. Conclusions: The use of IMS in metacarpal fracture fixation is a practicable surgical option. IMS fixations yields a satisfactory duration for return to function, good postoperative range of movement, modest pain scores and low rates of complications. Level of Evidence: Level IV (Therapeutic).
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  • 文章类型: Journal Article
    背景:两种前臂骨骨折(BBFF)都是儿科人群中常见的损伤。手术固定的主要适应症是开放性的,不可约,或者不稳定的骨折.两种最常用的手术技术是闭合或切开复位髓内固定(IMF)和切开复位钢板固定(PF)。本系统评价和荟萃分析的目的是确定哪种固定方法适用于BBFF。
    方法:PubMed,Scopus,WebofScience,和CENTRAL进行了搜索,以确定比较IMF和PF的研究。我们提取了工会率的数据,并发症,早期硬件去除率,再操作率,和射线照相,临床,和围手术期结果。
    结果:分析中包括16项研究,共有922例患者(539个IMF和383个PF)。两种固定技术均可实现相似的结合率。IMF与有症状硬件的发生率较高有关,和早期的硬件删除。PF组的桡骨弓恢复较好,尤其是年龄较大的儿童和青少年。两组间功能优良率相当,而国际货币基金组织小组报告了更好的宇宙观。尽管荧光透视时间和固定时间较短,PF显示更长的止血带时间,操作时间,与国际货币基金组织相比,住院时间。
    结论:考虑到每种技术的优缺点,我们发现IMF和PF在结合率和功能结果方面没有显着差异。高质量的随机对照试验,因此,必须确定一种固定技术相对于另一种的优越性。
    方法:III.
    BACKGROUND: Both bone forearm fractures (BBFFs) are a common injury amongst the pediatric population. The main indications of surgical fixation are open, irreducible, or unstable fractures. The two most commonly used surgical techniques are closed or open reduction with intramedullary fixation (IMF) and open reduction with plate fixation (PF). The aim of this systematic review and meta-analysis was to determine which fixation method is superior for BBFFs.
    METHODS: PubMed, Scopus, Web of Science, and CENTRAL were searched to identify studies comparing IMF and PF. We extracted data on union rates, complications, early hardware removal rates, reoperation rates, and radiographic, clinical, and perioperative outcomes.
    RESULTS: Sixteen studies were included in the analysis, with a total of 922 patients (539 IMF and 383 PF). Similar union rates were achieved by both fixation technique. IMF was associated with a higher incidence of symptomatic hardware, and early hardware removal. Better restoration of the radial bow was observed with the PF group, especially in older children and adolescents. The rate of excellent function was comparable between groups, whereas better cosmesis was reported with the IMF group. Despite shorter fluoroscopy time and immobilization time, PF demonstrated longer tourniquet time, operating time, and hospital stay compared to IMF.
    CONCLUSIONS: We found no significant difference between IMF and PF in terms of union rates and functional outcomes taking in consideration the merits and demerits of each technique. High-quality randomized controlled trials are, therefore, necessary to determine the superiority of one fixation technique over the other.
    METHODS: III.
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  • 文章类型: Case Reports
    脊髓髓内脓肿是一种罕见的神经系统疾病,不常怀疑,常误诊。即使经过及时的诊断和治疗,大多数患者持续存在永久性神经功能缺损。在成年人中,免疫功能受损等因素,静脉注射毒品,心内膜炎,脓毒症可能与其发展有关。在这项研究中,我们介绍了一例63岁的男性患者,该患者在接受椎旁肌和腰大肌多发性脓肿治疗后,出现了慢性颈髓内脊髓脓肿。诊断为继发于骨髓炎和椎间盘炎的颈髓内脊髓脓肿。他接受了两阶段的颈椎手术,脓肿的引流,脊柱稳定,还有静脉注射抗生素.虽然罕见,椎体骨髓炎和椎间盘炎可能与其发展有关。早期诊断,迅速脓肿引流,适当的抗生素治疗对于改善预后和减少永久性神经功能缺损的长期后遗症和并发症至关重要。
    Intramedullary spinal cord abscess is a rare neurological condition, not commonly suspected and often misdiagnosed. Even after a prompt diagnosis and treatment, most patients persist with permanent neurological deficits. In adults, factors such as immunocompromised, intravenous drug use, endocarditis, and sepsis could be associated with its development. In this study, we present the case of a 63-year-old male patient who developed a chronic cervical intramedullary spinal cord abscess after being treated for multiple abscesses in the paravertebral and psoas muscles. A diagnosis of cervical intramedullary spinal cord abscess secondary to osteomyelitis and discitis was made. He underwent a two-stage cervical surgery, with drainage of the abscess, spinal stabilization, and intravenous antibiotics. Although rare, vertebral osteomyelitis and discitis may be related to its development. Early diagnosis, prompt abscess drainage, and appropriate antibiotic therapy are of utmost importance to improve prognosis and minimize the long-term sequelae and complications of permanent neurological deficits.
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  • 文章类型: Journal Article
    反向股骨粗隆间斜骨折(ROFs)是不稳定的髋关节囊外骨折,存在机械挑战。根据创伤协会分类系统,这些骨折被分类为AO/骨科创伤协会(OTA)31-A3,并且可以基于它们的具体特征进一步细分为3个亚型。该研究旨在评估和比较3种ROFs亚型的影像学和临床结果。
    一项回顾性研究是在一项单一的大批量研究中进行的,三级中心,其中数据来自接受AO/OTA31-A3骨折手术固定术的连续患者的电子病历.随访时间少于1年的患者,病理性骨折,和翻修手术被排除。骨折的亚型被分类为31-A3.1(简单斜),31-A3.2(简单横向),和31-A3.3(楔形或多碎片)。手术采用4种不同的固定方法,放射学评估以常规间隔进行。
    最终人群包括265名患者(60.8%为女性),平均年龄为77.4岁(范围,50-100年),平均随访时间为35个月(范围,12-116个月)。各组医疗并发症的发生率相似。然而,31-A3.2组的骨科并发症发生率和翻修率有较高的趋势,尽管这没有统计学意义(分别为p=0.21和p=0.14)。
    根据本研究的结果,组间没有观察到显著差异,这表明AO/OTA31-A3骨折的亚分类对手术结局或术后并发症的发生没有显著影响.
    UNASSIGNED: Reverse oblique intertrochanteric fractures (ROFs) are unstable extracapsular hip fractures that present a mechanical challenge. These fractures are classified as AO/Orthopaedic Trauma Association (OTA) 31-A3 according to the Trauma Association classification system and can further be subclassified into 3 subtypes based on their specific characteristics. The study aimed to evaluate and compare the radiographic and clinical outcomes of the 3 subtypes of ROFs.
    UNASSIGNED: A retrospective study was conducted at a single high-volume, tertiary center, where data were collected from electronic medical records of consecutive patients who underwent surgical fixation of AO/OTA 31-A3 fractures. Patients with less than 1-year follow-up, pathological fractures, and revision surgery were excluded. The subtypes of fractures were classified as 31-A3.1 (simple oblique), 31-A3.2 (simple transverse), and 31-A3.3 (wedge or multi-fragmentary). The operation was done using 4 different fixation methods, and radiological evaluation was performed at routine intervals.
    UNASSIGNED: The final population consisted of 265 patients (60.8% women) with a mean age of 77.4 years (range, 50-100 years) and the mean follow-up time was 35 months (range, 12-116 months). The incidence of medical complications was similar across the groups. However, there was a trend toward a higher incidence of orthopedic complications and revision rates in the 31-A3.2 group, although this was not statistically significant (p = 0.21 and p = 0.14, respectively).
    UNASSIGNED: Based on the findings of this study, no significant differences were observed between the groups, indicating that the subclassifications of AO/OTA 31-A3 fractures do not have a significant impact on surgical outcomes or the occurrence of postoperative complications.
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  • 文章类型: Systematic Review
    背景:髓内脑膜瘤是一种极为罕见的脊柱肿瘤亚型,仅占原发性脊柱肿瘤的5%。鉴于它们的稀缺性和独特的特征,了解最佳管理方法对于改善临床决策至关重要。本系统综述旨在巩固现有文献,并提供详细的病例说明,以增强对这种罕见脊柱肿瘤实体的理解。
    方法:根据系统评价和Meta分析指南的首选报告项目进行系统检索。符合条件的研究包括病例报告,案例系列,队列研究,reviews,和荟萃分析。数据提取和综合侧重于人口特征,肿瘤位置,临床表现,影像学发现,手术干预,组织病理学特征,和结果。
    结果:系统评价共纳入15篇高质量的科学文章,提供有关髓内脑膜瘤各个方面的见解。人口统计学分析显示,受影响患者的年龄分布广泛,性别分布相等。常见的临床表现包括行走困难,感觉障碍,痉挛性轻瘫,和尿失禁.神经影像学检查结果表明,T1和T2加权图像上的信号强度变化不均匀,在钆增强的图像上具有可变的增强模式。手术干预,主要是全切除,在大多数情况下导致良好的术后结局。
    结论:髓内脑膜瘤由于其稀有性和独特的特点,提出了诊断和治疗的挑战。量身定制的手术方法,结合术中神经生理监测和荧光辅助切除等技术,对于减少神经功能缺损和优化患者预后至关重要。尽管他们的频率不高,在脊柱肿瘤的鉴别诊断中认识髓内脑膜瘤对于及时诊断和及时干预至关重要。最终改善患者预后。
    BACKGROUND: Intramedullary meningiomas are an exceptionally rare subtype of spinal tumors, accounting for only 5% of primary spinal neoplasms. Given their scarcity and unique characteristics, understanding optimal management approaches is crucial for improved clinical decision-making. This systematic review aims to consolidate existing literature and present a detailed case illustration to enhance understanding of this uncommon spinal tumor entity.
    METHODS: A systematic search adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted. Eligible studies included case reports, case series, cohort studies, reviews, and meta-analyses. Data extraction and synthesis focused on demographic characteristics, tumor location, clinical presentation, imaging findings, surgical interventions, histopathological features, and outcomes.
    RESULTS: A total of 15 high-quality scientific articles were included in the systematic review, providing insights into various aspects of intramedullary meningiomas. Demographic analysis revealed a broad age distribution with an equal gender distribution among affected patients. Common clinical presentations included difficulty walking, sensory disturbances, spastic paraparesis, and urinary incontinence. Neuroimaging findings demonstrated heterogeneous signal intensity variations on T1- and T2-weighted images, with variable enhancement patterns on gadolinium-enhanced images. Surgical interventions, predominantly total resection, resulted in favorable postoperative outcomes in most cases.
    CONCLUSIONS: Intramedullary meningiomas pose diagnostic and therapeutic challenges due to their rarity and unique characteristics. Tailored surgical approaches, incorporating techniques such as intraoperative neurophysiological monitoring and fluorescence-aided resection, are crucial for minimizing neurological deficits and optimizing patient outcomes. Despite their infrequency, recognizing intramedullary meningiomas in the differential diagnosis of spinal tumors is essential for prompt diagnosis and timely intervention, ultimately improving patient prognosis.
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  • 文章类型: Journal Article
    指骨和掌骨骨折的髓内螺钉固定已成为一种以最小的肌腱干扰提供刚性内固定的方法,允许早期动员和康复。尽管如此,关于使用该技术的结局的文献有限.因此,本研究的目的是评估澳大利亚地区髓内螺钉内固定治疗指骨近端骨折的短期至中期结局.
    通过远程医疗对2020年1月至2023年3月期间使用髓内螺钉固定的近端指骨骨折的连续患者进行了回顾性分析。
    本研究纳入了37例患者的46个指骨骨折。手臂的平均快速残疾,肩膀,手评分为6.2(范围:0-61.4,中位数:0),平均疼痛视觉模拟评分1.8分(范围:1-7,中位数:1),注意到平均总主动运动为231°(范围:132-282)。总共4.4%的骨折持续了严重的并发症,94.6%的患者表示愿意再次进行髓内螺钉固定。
    这项研究与先前的文献一致,即髓内螺钉固定是一种安全有效的方法,可在短期至中期内稳定关节外近指骨骨折。优越的临床结果,以及成本效益和时间效益,使其成为这种情况下钢板固定的可行替代方案。
    UNASSIGNED: Intramedullary screw fixation of phalangeal and metacarpal fractures has gained popularity as a method of providing rigid internal fixation with minimum tendon disturbance, allowing early mobilization and rehabilitation. Despite this, the literature on outcomes using this technique is limited. Thus, the aim of this study was to assess the short-term to medium-term outcomes of intramedullary screw fixation for proximal phalangeal fracture fixation in an Australian setting.
    UNASSIGNED: A retrospective analysis of consecutive patients with a fracture(s) of the proximal phalanx fixated using intramedullary screws between January 2020 and March 2023 was conducted via telehealth.
    UNASSIGNED: Forty-six phalangeal fractures from 37 patients were included in this study. Mean Quick Disabilities of the Arm, Shoulder, and Hand score of 6.2 (range: 0-61.4, median: 0), mean pain visual analogue scale score of 1.8 (range: 1-7, median: 1), and mean total active motion of 231° (range: 132-282) were noted. A total of 4.4% of fractures sustained a major complication, and 94.6% of patients reported willingness to undergo intramedullary screw fixation again.
    UNASSIGNED: This study concurs with the prior literature that intramedullary screw fixation is a safe and effective method of stabilizing extra-articular proximal phalangeal fractures in the short to medium term. Superior clinical outcomes, as well as cost-effectiveness and time-effectiveness, render it a viable alternative to plate fixation in this setting.
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  • 文章类型: Case Reports
    背景:脊柱肿瘤占所有中枢神经系统肿瘤的15%,神经鞘瘤占原发性椎管内肿瘤的30%。虽然主要是髓外硬膜内,脊髓神经鞘瘤很少出现髓内病变(占椎管内肿瘤的0.3%)。这项研究揭示了两例罕见的胸髓内神经鞘瘤,强调他们的诊断复杂性和手术管理,除了文献综述。
    方法:病例1涉及一名50岁女性背痛加重,右下肢无力,和尿失禁.MRI显示硬膜内髓内软组织肿块,诊断为神经鞘瘤并伴有组织性血肿。手术切除导致逐步改善。案例2以一名25岁男性背痛为特征,部分足下垂,右膝和髋部无力.MRI显示硬膜内髓内病变,后来证实为硬膜内髓内神经鞘瘤。手术恢复顺利,无不良反应。
    结论:本文介绍了2例最初误诊为星形细胞瘤的胸椎髓内神经鞘瘤。手术切除证实了诊断,强调术前MRI诊断的挑战。对174例报告病例的回顾显示,颈部和胸部区域分布相等,男性受影响的频率是女性的1.5倍。平均发病年龄为40岁,手术治疗显示出90%的改善率。复杂的发病机制包括六种建议的解释。临床怀疑,考虑到疼痛和神经症状,由于潜在的误诊和组织学确认的必要性,这是至关重要的。
    结论:虽然罕见,髓内神经鞘瘤(IMS)具有重要的临床意义,需要精确的治疗。手术切除产生良好的结果,根据粘连因素考虑次全切除。术前诊断需要全面整合放射学和临床资料,术中分析确保最佳治疗策略。
    BACKGROUND: Spinal tumors comprise 15 % of all central nervous system tumors, with schwannomas accounting for 30 % of primary intraspinal neoplasms. While predominantly extramedullary-intradural, spinal schwannomas rarely manifest intramedullary occurrences (0.3 % of intraspinal tumors). This study sheds light on two rare cases of thoracic intramedullary schwannomas, emphasizing their diagnostic complexities and surgical management, alongside a literature review.
    METHODS: Case 1 involves a 50-year-old female presenting with worsening back pain, right lower limb weakness, and urinary incontinence. MRI revealed an intradural intramedullary soft tissue mass, diagnosed as a schwannoma with an associated organizing hematoma. Surgical removal led to gradual improvement. Case 2 features a 25-year-old male with back pain, partial foot drop, and weakness in the right knee and hip. MRI demonstrated an intradural intramedullary lesion, later confirmed as an intradural intramedullary schwannoma. Surgery resulted in a smooth recovery without adverse effects.
    CONCLUSIONS: This article presents two cases of intradural intramedullary thoracic schwannomas initially misdiagnosed as astrocytomas. Surgical resection confirmed the diagnosis, underscoring challenges in preoperative MRI diagnosis. The review of 174 reported cases reveals an equal distribution between the cervical and thoracic regions, with males affected 1.5 times more frequently than females. The average age of onset is 40, and surgical treatment demonstrates a 90 % improvement rate. The complex pathogenesis encompasses six proposed explanations. Clinical suspicion, considering pain and neurological symptoms, is paramount due to potential misdiagnosis and the imperative for histological confirmation.
    CONCLUSIONS: Although rare, intramedullary schwannomas (IMS) have significant clinical implications, necessitating precise treatment. Surgical resection yields favorable outcomes, with subtotal resection considered based on adhesion factors. Pre-surgical diagnosis requires a comprehensive integration of radiological and clinical data, with intraoperative analysis ensuring optimal treatment strategies.
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