PDF(Pubmed)
Abstract：
Benzoxazole and benzothiazole have a broad spectrum of agricultural biological activities, such as antibacterial, antiviral, and herbicidal activities, which are important fused heterocyclic scaffold structures in agrochemical discovery. In recent years, great progress has been made in the research of benzoxazoles and benzothiazoles, especially in the development of herbicides and insecticides. With the widespread use of benzoxazoles and benzothiazoles, there may be more new products containing benzoxazoles and benzothiazoles in the future. We systematically reviewed the application of benzoxazoles and benzothiazoles in discovering new agrochemicals in the past two decades and summarized the antibacterial, fungicidal, antiviral, herbicidal, and insecticidal activities of the active compounds. We also discussed the structural-activity relationship and mechanism of the active compounds. This work aims to provide inspiration and ideas for the discovery of new agrochemicals based on benzoxazole and benzothiazole.
摘要：
苯并恶唑和苯并噻唑具有广谱的农业生物活性，如抗菌，抗病毒，和除草活性，它们是农业化学发现中重要的稠合杂环支架结构。近年来,苯并恶唑和苯并噻唑的研究取得了很大进展，特别是在除草剂和杀虫剂的开发中。随着苯并恶唑和苯并噻唑的广泛应用,未来可能会有更多含有苯并恶唑和苯并噻唑的新产品。系统回顾了近二十年来苯并恶唑和苯并噻唑在发现新型农用化学品中的应用,杀真菌剂,抗病毒，除草,和活性化合物的杀虫活性。我们还讨论了活性化合物的结构-活性关系和机理。本工作旨在为基于苯并恶唑和苯并噻唑的新型农用化学品的发现提供启示和思路。
